Publications by authors named "A A Ries"
The worldwide frequency of head and neck squamous cell carcinoma (HNSCC) is approximately 800,000 new cases, with 430,000 deaths annually. We determined that LZK (encoded by ) is a therapeutic target in HNSCC and showed that inhibition with small molecule inhibitors decreases the viability of HNSCC cells with amplified . A drug-resistant mutant of LZK blocks decreases in cell viability due to LZK inhibition, indicating on-target activity by two separate small molecules.
View Article and Find Full Text PDFDetection of DNA of Leishmania infantum in the brains of dogs without neurological signs in an endemic region for leishmaniasis in the state of Rio Grande do Sul, Brazil.
Parasitol Res
November 2024
Article Synopsis
- * A study examined 200 dogs in Rio Grande do Sul, Brazil, for the presence of Leishmania spp., using PCR techniques; 26.5% tested positive, all for L. infantum, with an average age of 5.08 years among the infected.
- * Clinical signs in infected dogs varied, with some showing symptoms like hepatomegaly and anemia; notable pathological findings included evidence of distemper and meningitis in certain cases.
Article Synopsis
- A digital self-efficacy training program was developed to help university students recall personal successes to improve mental health outcomes.
- In a study involving 93 students with high stress, those who completed the training reported lower levels of hopelessness and anxiety compared to a control group.
- The training was linked to increased self-efficacy and showed promising results, but more research is needed to confirm its long-term benefits and potential use in clinical settings.
Introduction: In real-life scenarios, individuals frequently engage in tasks that involve searching for one of the distinct items stored in memory. This combined process of visual search and memory search is known as hybrid search. To date, most hybrid search studies have been restricted to average observers looking for previously well-memorized targets in blank backgrounds.
View Article and Find Full Text PDFIn animals, stem cell populations of varying potency facilitate regeneration and tissue homeostasis. Notably, germline stem cells in both vertebrates and invertebrates express highly conserved RNA binding proteins, such as , , and . In highly regenerative animals, these genes are also expressed in somatic stem cells, which led to the proposal that they had an ancestral role in all stem cells.
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