Publications by authors named "A A Quyyumi"
Background: Higher soluble urokinase plasminogen activator receptor (suPAR) levels are associated with adverse outcomes in chronic heart failure (HF).
Objectives: The authors assessed the association between proteomics-based suPAR levels and incident HF risk in the general population.
Methods: In 40,418 UK Biobank participants without HF or coronary artery disease at enrollment, the association between Olink-based suPAR levels measured as relative protein expression levels and incident all-cause, ischemic, and nonischemic HF was analyzed by competing-risk regression, while accounting for all-cause death as a competing risk.
Background: Although sex differences in coronary artery disease (CAD) risk have been observed, little is known about the role of sex hormones in CAD genetics. Accounting for sex hormone levels may help identify CAD-risk loci and extend our knowledge of its genetic architecture.
Methods And Results: A total of 365 662 individuals of European ancestry enrolled in the UK Biobank were considered.
Objective: To examine inpatient COVID-19-related outcomes among patients with and without diabetes alone or with a history of established heart failure (HF) or established atherosclerotic cardiovascular disease (ASCVD).
Design: Observational study; longitudinal analysis of registry data.
Setting: Hospitals in the USA reporting to the American Heart Association (AHA) COVID-19 Registry from January 2020 to May 2021.
Aims: The mechanisms linking acute psychological stress to cardiovascular disease (CVD) mortality are incompletely understood. We studied the relationship of electrocardiographic measures of autonomic dysfunction during acute mental stress provocation and CVD death.
Methods And Results: In a pooled cohort of 765 participants with stable CVD from two related studies, we collected Holter data during standardized laboratory-based mental stress testing with a speech task and followed them for events.
Article Synopsis
- PTSD is linked to a higher risk of heart failure hospitalizations in individuals with coronary artery disease, with those diagnosed having a 4.4 times greater risk of hospitalizations compared to those without PTSD.
- The study involved 736 participants, revealing that 9.4% had PTSD, and higher PTSD symptom scores correlated with increased heart failure events.
- While PTSD is strongly associated with heart failure, it does not appear to influence rates of cardiovascular death or nonfatal heart attacks unrelated to heart failure hospitalizations.