Effect of adrenalectomy on healing of indomethacin-induced gastric erosions in rats.

We studied the effects of adrenalectomy and replacement therapy on healing of gastric erosions in adult Sprague-Dawley rats developed 4 h after subcutaneous injection of indomethacin in a dose of 25 or 35 mg/kg. Adrenalectomy was performed 1 week before or 4 h after indomethacin administration. Healing was evaluated by changes in the area of erosions over 24 h after indomethacin administration at fixed time intervals.

[The effect of stress and corticosteroids on the rate of blood flow in the microvessels of the gastric muscular coat of rats].

In order to evaluate the influence of stress and corticosteroids on blood flow velocity in microvessels of muscular coat of the stomach we applied intravital microfilming by means of a dark-field contact epiobjective. The plasma filled "gap" in the continuous erythrocyte flow were used as the markers to measure linear flow velocity. In unstressed rats the velocity was equal to 1.