Publications by authors named "A A Prokof'eva-Bel'govskaia"

Polymorphism of the heterochromatic regions (HR) on chromosomes 1, 9, 16 and in three groups of boys at the age of 3 to 14 years was studied. Two groups of boys with olygophrenia of unknown etiology differed by the extent of mental defect, the latter being debility in 50 children, while other 50 children had the profound mental defect. The control group consisted of 50 healthy children.

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The functional relationship between the transformations of chromosome structure and parallel changes of its major components, i. e. DNA, histones and non-histone proteins (NHP) has been analysed.

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The variability of heterochromatic regions on chromosomes 1, 9, 16 and Y has been studied in a group of unrelated subjects (50 boys and 50 girls) using quantitative methods. Analysis of intercellular (with one subject) variability of chromosome C-segments lengths has shown that their absolute lengths vary considerably with the cell sample examined, while the relative lengths (a part of the total length of C-segment of the chromosomes being studied) are more stable. The relative lengths may be helpful in individual characteristics, reproducible in repeated analysis, which may be used in zygosity testing in twins, family analysis, etc.

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The investigation of chromosome polymorphism by quantitative methods is a rather hard task. The manual method for measuring C-segments of chromosomes 1, 9, 16 and Y in man is suggested, which is not difficult, being reasonably precise for the population research. Metaphases of the average level of chromosome condensation were taken for analysis.

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