Publications by authors named "A A Potapov"
Background/objectives: This study focuses on the development and evaluation of novel alginate-poly[2-(methacryloyloxy)ethyl]trimethylammonium chloride (PMETAC) microcapsules for encapsulating pancreatic islets to address insulin deficiency in diabetes.
Methods: In previous research, we fabricated and characterized PMETAC microcapsules, evaluating their stability and permeability in vitro. This study further probes the capsules in vivo, focusing on the functional activity of the encapsulated islets post-transplantation, their viability extension, and the assessment of the immunoprotective, antifibrotic properties, and biostability of the capsules.
Article Synopsis
- Resistance to chemotherapy in colorectal cancer may be linked to cell-in-cell (CIC) structures, where one cell protects another from harmful treatments.
- Studies using advanced microscopy techniques showed that resistance to drugs like oxaliplatin and Irinotecan was associated with an increased formation of CIC structures in cancer cells.
- The findings suggest that CIC structures could serve as a potential marker for predicting treatment success in colorectal cancer, warranting further clinical research.
Biodiversity experiments revealed that plant diversity loss can decrease ecosystem functions across trophic levels. To address why such biodiversity-function relationships strengthen over time, we established experimental mesocosms replicating a gradient in plant species richness across treatments of shared versus non-shared history of (1) the plant community and (2) the soil fauna community. After 4 months, we assessed the multitrophic functioning of soil fauna via biomass stocks and energy fluxes across the food webs.
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- The research investigates how different types of glial tumors in rats affect the attenuation coefficient of white matter in the brain, showing varied impacts based on tumor type and malignancy.
- Some tumors lead to a significant drop in this coefficient due to cell infiltration and damage to myelinated fibers, while others compress fibers without major destruction.
- The study also highlights the potential of using the attenuation coefficient, derived from OCT data, to identify late radiation damage in white matter, suggesting its usefulness for evaluating tissue health around tumors during surgeries.
Climate change and land-use intensification are threatening soil communities and ecosystem functions. Understanding the combined effects of climate change and land use is crucial for predicting future impacts on soil biodiversity and ecosystem functioning in agroecosystems. Here, we used a field experiment to quantify the combined effects of climate change (warming and altered precipitation patterns) and land use (agricultural type and management intensity) on soil food webs across nematodes, micro-, and macroarthropods.
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