Publications by authors named "A A Poloznikov"
Relapse of breast cancer is one of the key obstacles to successful treatment. Previously we have shown that low expression of and genes in breast cancer tissue corresponded to poor prognosis. participates directly in the elongation of polyunsaturated fatty acids (PUFAs) that are considered to play an important role in cancer cell metabolism.
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- This study compares the effectiveness of 2-oxoglutarate mimetics and branched-tail oxyquinoline inhibitors in activating HIF prolyl hydroxylase, focusing on their performance in a luciferase reporter assay.
- Novel oxyquinoline inhibitors identified in this research showed significantly higher potency than existing drugs like roxadustat and vadadustat, especially when 2-methyl substitution was applied.
- Transcriptomic analysis revealed that the new inhibitors stimulated HIF1 and HIF2 pathways similarly to roxadustat but had distinct effects on alternative pathways involving p53 and NF-κB, suggesting a specific action of the 2-methyl variant on HIF PHD2.
Ginsenoside Rh2 increases the efficacy of doxorubicin (DOX) treatment in murine models of solid and ascites Ehrlich's adenocarcinoma. In a solid tumor model (treatment commencing 7 days after inoculation), DOX + Rh2 co-treatment was significantly more efficacious than DOX alone. If treatment was started 24 h after inoculation, the inhibition of tumor growth of a solid tumor for the DOX + Rh2 co-treatment group was complete.
View Article and Find Full Text PDFColorectal cancer (CRC) is one of the most common and lethal types of cancer. Although researchers have made significant efforts to study the mechanisms underlying CRC drug resistance, our knowledge of this disease is still limited, and novel therapies are in high demand. It is urgent to find new targeted therapy considering limited chemotherapy options.
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