Publications by authors named "A A Pigoso"
Rheumatoid arthritis (RA) causes inflammation, pain, edema, and articular degradation and its treatment can be based on anti-inflammatory drugs, photobiomodulation (PBM) and/or platelet-rich plasma (PRP) that can decrease cell flow and promote local healing. In the present study, we evaluate the effects of PBM and PRP on acute arthritis in Wistar rats through inflammatory and oxidative stress parameters. Thirty female Wistar rats were assigned to five groups (n=6, each group): Control, Sham, PRP, Laser, and PRP+Laser.
View Article and Find Full Text PDFCrotamine is a single-chain polypeptide with cell-penetrating properties, which is considered a promising molecule for clinical use. Nevertheless, its biosafety data are still scarce. Herein, we assessed the in vivo proinflammatory properties of crotamine, including its local effect and systemic serum parameters.
View Article and Find Full Text PDFStudies focusing on possible genotoxic effects of excess fluoride are contradictory and inconclusive. Currently, studies have reported a probable link to oxidative stress, DNA damage and apoptosis induced by fluoride in rat hepatocytes. We developed an in vivo study administering three doses of fluoride by gavage given to rats for 60 day.
View Article and Find Full Text PDFArticle Synopsis
- São Paulo is a major global center for sugar cane production, leading to extensive use of the herbicide ametryn, which can contaminate various environmental elements.
- An in vivo study on Wistar rats tested the toxicity of two sub-lethal concentrations of ametryn over 56 days, revealing genotoxic effects linked to oxidative stress and changes in certain gene expressions.
- The findings highlighted significant alterations in liver cell behavior and structure, indicating potential health risks associated with ametryn exposure, while suggesting the need for further research on cell death and proliferation to fully understand its toxicity.
Ametryn is an herbicide used to control broadleaf and grass weeds and its acute and chronic toxicity is expected to be low. Since toxicological data on ametryn is scarce, the aim of this study was to evaluate rat reproductive toxicity. Thirty-six adult male Wistar rats (90 days) were divided into three groups: Co (control) and T1 and T2 exposed to 15 and 30 mg/kg/day of ametryn, respectively, for 56 days.
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