Publications by authors named "A A Padula"
Background: Per- and polyfluoroalkyl substances (PFAS) are persistent and ubiquitous chemicals posing environmental and health risks. Impact on the human immune system is of particular concern, especially during fetal immune development. Alterations to fetal immune development can impact immunity later in life, e.
View Article and Find Full Text PDFAlthough men have historically exhibited higher levels of alcohol use disorder (AUD) diagnosis, the gap between men and women has been diminishing quickly. Preclinical screening for pharmacological treatments for AUD has typically focused solely on males, ignoring the possibility that males and females may differ mechanistically for the same behavioral phenotype. To ensure the efficacy of treatment targets across the sexes, it is crucial to study the pharmacological effects of AUD treatments in males and females.
View Article and Find Full Text PDFArticle Synopsis
- - This study is the first to analyze the presence of anthropogenic microparticles in franciscana dolphins, the most endangered cetaceans in the Southwest Atlantic Ocean, using samples from ten female dolphins collected between 2013 and 2023.
- - Analysis of the intestinal content and wall tissues revealed that all samples contained anthropogenic particles, primarily in the form of fibers, with various types of polymers like polyester and polypropylene identified through advanced spectroscopic techniques.
- - The research indicated differences in the types and colors of microplastics found in various sections of the dolphin's intestines, highlighting the extent of microplastic absorption in these endangered animals.
Alcohol use disorder (AUD) is the most prevalent substance use disorder but there is incomplete knowledge of the underlying molecular etiology. Here, we examined the cytosolic proteome from the nucleus accumbens core (NAcC) of ethanol drinking rhesus macaques to identify ethanol-sensitive signaling proteins. The targets were subsequently investigated using bioinformatics, genetic, and pharmacological manipulations in mouse models of ethanol drinking.
View Article and Find Full Text PDFPregnant people are vulnerable to air pollution exposure, including risk of preterm birth, low birth weight, and stillbirth. Understanding the infiltration of outdoor wildfire smoke into a residential space is critical for the accurate assessment of wildfire smoke exposure and associated health effects in pregnant people. Relying on ambient measurements of wildfire smoke alone can result in exposure misclassification.
View Article and Find Full Text PDF