Shape Measurement of Single Gold Nanorods in Water Using Open-Access Optical Microcavities.

Shape measurement of single nanoparticles in fluids is an outstanding challenge with applications in characterizing synthetic functional nanoparticles and in early warning detection of rod-shaped pathogens in water supplies. Here we introduce a novel technique to measure the aspect ratio of rod-shaped particles by analyzing changes in the polarization state of a laser beam transmitted through an optical microcavity through which the particle diffuses. The resolution in aspect ratio measurement is found to be around 1%.

Characterization of nanoparticle size distributions using a microfluidic device with integrated optical microcavities.

We introduce a method for analyzing the physical properties of nanoparticles in fluids the competition between viscous drag and optical forces in a microfluidic device with integrated optical microcavities. The optical microcavity acts as a combined optical trap and sensor, such that the time duration of individual particle detection events can be used as a measure of particle size a parameter which represents the dielectric polarizability per unit radius. Characterization of polymer particles with diameters as small as 140 nm is reported, below that used in previous optical sorting approaches and in the size range of interest for nanomedicine.

Evaluation of Loco-Regional Skin Toxicity Induced by an In Situ Forming Depot after a Single Subcutaneous Injection at Different Volumes and Flow Rates in Göttingen Minipigs.

The present study aims to investigate the loco-regional tolerability and injection parameters (i.e., flow rate and administration volume) of an in situ forming depot (ISFD) in Göttingen minipigs, to secure both the therapeutic procedure and compliance in chronic medical prescriptions.

Bespoke mirror fabrication for quantum simulation with light in open-access microcavities.

In this work, we use focused ion beam (FIB) milling to generate custom mirror shapes for quantum simulation in optical microcavities. In the paraxial limit, light in multimode optical microcavities follows an equation of motion which is equivalent to Schrödinger's equation, with the surface topography of the mirrors playing the role of the potential energy landscape. FIB milling allows us to engineer a wide variety of trapping potentials for microcavity light, through exquisite control over the mirror topography, including 2D box, 1D waveguide, and Mexican hat potentials.

Universal Scaling in the Dynamic Hysteresis, and Non-Markovian Dynamics, of a Tunable Optical Cavity.

We investigate, experimentally and theoretically, the dynamics of a laser-driven cavity with noninstantaneous effective photon-photon interactions. Scanning the laser-cavity frequency detuning at different speeds across an optical bistability, we find a hysteresis area that is a nonmonotonic function of the speed. In the limit of fast scans comparable to the memory time of the interactions, we demonstrate that the hysteresis area decays following a universal power law with scaling exponent -1.