[A computer study of the relationship between the value and type of their embryotoxicity and the structure of synthetic analogs of biogenic amines].

We calculated 219 topological, electronic, and steric indices for each of 59 studied embryotoxic benzylalkylamines and indolamines. Statistically significant equations correlating embryotoxicity and five calculated parameters were obtained using the method of step multiple regression. The prognostic power of the equation was 88-90%.

[The computer prognosis of the phenomenon of the superactivity neuropharmacological embryotoxic preparations by using molecular topological parameters and the methods of the sample recognition theory].

Discriminant functions were obtained on the basis of experimental data on the superactivity of synthetic analogues of the natural biogenic amines (26 active and 33 superactive derivatives of benzene and indole), which allow prognostication of the superactivity of embryotoxic compounds with respect to sea urchin embryos on the basis of calculated parameters of the molecules. During reclassification of molecules of the learning sample, the percentage of correct recognition is 73.1 for active, 87.

[The prediction of the superactivity of embryo-toxic benzine and indole derivatives by the discriminant analysis method].

The discriminant functions allowing to predict the phenomenon of superactivity for some embryotoxic neurochemicals by means of tabular electronic and lipophilic parameters are received. The prognosis possibility of the received functions for benzene and indole derivatives on the sea urchin embryos is about 93%.

[Pharmacokinetics of nifedipine after a single oral dose in patients with disorders of cerebral circulation].

The pharmacokinetics of nifedipine was studied in 44 patients with disorders of cerebral circulation. A significant variability of the pharmacokinetic parameters in different patients was revealed. According to the results of the cluster-analysis, the main types (classes) of nifedipine pharmacokinetics were established and the possibility of regarding the patient examined as having this or that type during the measurement of the blood nifedipine concentration 2, 3 and 4 hours after administration of the drug was shown.