Searching for New Biomarkers to Assess COVID-19 Patients: A Pilot Study.

During the initial diagnosis of urgent medical conditions, which include acute infectious diseases, it is important to assess the severity of the patient's clinical state as quickly as possible. Unlike individual biochemical or physiological indicators, derived indices make it possible to better characterize a complex syndrome as a set of symptoms, and therefore quickly take a set of adequate measures. Recently, we reported on novel diagnostic indices containing butyrylcholinesterase (BChE) activity, which is decreased in COVID-19 patients.

Sentence comprehension test for Russian: A tool to assess syntactic competence.

Although all healthy adults have advanced syntactic processing abilities in their native language, psycholinguistic studies report extensive variation among them. However, very few tests were developed to assess this variation, presumably, because when adult native speakers on syntactic processing, by other tasks, they usually reach ceiling performance. We developed a Sentence Comprehension Test for the Russian language aimed to fill this gap.

A Comparative Study on the Effects of the Lysine Reagent Pyridoxal 5-Phosphate and Some Thiol Reagents in Opening the Tl-Induced Mitochondrial Permeability Transition Pore.

Lysine residues are essential in regulating enzymatic activity and the spatial structure maintenance of mitochondrial proteins and functional complexes. The most important parts of the mitochondrial permeability transition pore are F1F0 ATPase, the adenine nucleotide translocase (ANT), and the inorganic phosphate cotransporter. The ANT conformation play a significant role in the Tl-induced MPTP opening in the inner membrane of calcium-loaded rat liver mitochondria.

The Joint Influence of Tl and Thiol-Modifying Agents on Rat Liver Mitochondrial Parameters In Vitro.

Recent data have shown that the mitochondrial permeability transition pore (MPTP) is the complex of the Ca-modified adenine nucleotide translocase (ANT) and the Ca-modified ATP synthase. We found in a previous study that ANT conformational changes may be involved in Tl-induced MPTP opening in the inner membrane of Ca-loaded rat liver mitochondria. In this study, the effects of thiol-modifying agents (eosin-5-maleimide (EMA), fluorescein isothiocyanate (FITC), Cu(o-phenanthroline) (Cu(OP)), and embelin (Emb)), and MPTP inhibitors (ADP, cyclosporine A (CsA), n-ethylmaleimide (NEM), and trifluoperazine (TFP)) on MPTP opening were tested simultaneously with increases in swelling, membrane potential (ΔΨ) decline, decreases in state 3, 4, and 3U (2,4-dinitrophenol-uncoupled) respiration, and changes in the inner membrane free thiol group content.