Publications by authors named "A A Nedorubov"
The replenishment of bone deficiency remains a challenging task in clinical practice. The use of gene-activated matrices (GAMs) impregnated with genetic constructs may be an innovative approach to solving this problem. The aim of this work is to develop collagen-based matrices with the addition of platelet-rich plasma, carrying polyplexes with the gene, to study their biocompatibility and osteogenic potential in vitro and in vivo.
View Article and Find Full Text PDFImmunogenicity and Protectivity of Sputnik V Vaccine in hACE2-Transgenic Mice against Homologous and Heterologous SARS-CoV-2 Lineages Including Far-Distanced Omicron BA.5.
Vaccines (Basel)
October 2024
Article Synopsis
- The SARS-CoV-2 virus mutates continuously, leading to new variants like Omicron, which has reduced the effectiveness of vaccines worldwide.
- The study evaluated the Sputnik V vaccine's effectiveness against several SARS-CoV-2 variants using various research methods on transgenic mice.
- Results showed that while Sputnik V generates a strong immune response, its efficacy is significantly lower against the Omicron variant, highlighting the need for ongoing monitoring and potential development of new vaccines.
Article Synopsis
- Recent research shows ribavirin can effectively treat glioblastoma using an intranasal delivery method that targets the brain directly.
- The study focused on improving ribavirin's bioavailability by using gel-forming polymers in the nasal cavity, incorporating thermosensitive, pH-sensitive, and ion-selective materials.
- The optimal gel composition was determined as 0.5% gellan gum, 2% Poloxamer 124, and a 100 mg/mL concentration of ribavirin, and in vivo tests demonstrated successful drug penetration into the brain via the olfactory pathways in male rats.
The impaired function of the serotonin transporter (SERT) in humans has been linked to a higher risk of obesity and type 2 diabetes, especially as people age. Consuming a "Western diet" (WD), which is high in saturated fats, cholesterol, and sugars, can induce metabolic syndrome. Previous research indicated that mice carrying a targeted inactivation of the gene (knockout, KO) and fed a WD display significant metabolic disturbances and behaviors reminiscent of ADHD.
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- * After 6 weeks, all DMSO concentrations reduced myelin content, while 0.1% DMSO for 4 weeks and 1% DMSO for 6 weeks significantly improved motor coordination as shown in the rotarod test (p<0.05 and p<0.001, respectively).
- * The study also found mixed effects on pain sensitivity, where lower concentrations of D