Prognostic significance of microRNA 17-92 cluster expression in Egyptian chronic lymphocytic leukemia patients.

Background: Abnormal expression patterns of microRNAs (miRs) play an important role in the development and progression of malignancy. Identification of the clinical significance and prognostic value of these small molecules in chronic lymphocytic leukemia (CLL); a disease of heterogeneous biological landscape and clinical course, has always been of tremendous translational value.

Aim: To evaluate the prognostic value of microRNA17-92 cluster members in Egyptian CLL patients.

Immunological properties of cellular and whole-culture leptospiral bacterins.

Two bivalent leptospiral bacterins were compared for safety in guinea pigs and for potency in hamsters. One bacterin (Bacterin A) was prepared from the cellular material of Leptospiral icterohaemorrhagiae and Leptospira canicola cultures propagated in Stuart's modified medium with 7% rabbit serum. The 2nd bacterin (Bacterin B) contained whole leptospiral cultures grown in synthetic medium.