In Silico design and molecular dynamics analysis of imidazole derivatives as selective cyclooxygenase-2 inhibitors.

Cyclooxygenase-2 (COX-2), a key enzyme in the inflammatory pathway, is the target for various nonsteroidal anti-inflammatory drugs (NSAIDs) and selective inhibitors known as coxibs. This study focuses on the development of novel imidazole derivatives as COX-2 inhibitors, utilizing a Structure-Activity Relationship (SAR) approach to enhance binding affinity and selectivity. Molecular docking was performed using Autodock Vina, revealing binding energies of -6.

[Comparative characteristics of diagnostic methods of primary hyperparathyroidism in patients with urolithiasis].

Nephrolithiasis (NL) is a frequent complication of hyperparathyroidism (HPT). Such patients account for 5% of those with nephrolithogenesis. The study included 89 HPT patients (age 34.

[The finding of the eggs of the nematode Eustrongylides excisus in true sturgeons of the Caspian Sea].

The finding of eggs of the nematode Eustrongylides excisus has been reported from true sturgeons of the Caspian Sea. The nematode is in the capsule with an opening into the cavity of the alimentary canal. In addition to birds, true sturgeons are expected to be under certain conditions definitive hosts of this nematode.