Secondary intact capsulectomy with seroma without implant: revision of an incomplete treatment of BIA-ALCL - a case report.

Background: Breast Implant Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) is a haematological malignancy which may occur in patients with textured breast implant history. While typically diagnosed at an early stage with good prognosis, it may present with local residual disease due to incomplete surgical excision.

Case Presentation: We describe the case of a 42 year-old woman with a history of bilateral breast augmentation for cosmetic purposes 21 years prior, who developed recurring seroma of the left side.

Digital Twin-Assisted Lightpath Provisioning and Nonlinear Mitigation in C+L+S Multiband Optical Networks.

Multiband (MB) optical transmission targets increasing the capacity of operators' optical transport networks. However, nonlinear impairments (NLI) affect each optical channel in the C+L+S bands differently, and, therefore, the routing and spectrum assignment (RSA) problem needs to be complemented with fast and accurate tools to consider the quality of transmission (QoT) within the provisioning process. This paper proposes a digital twin-assisted approach for lightpath provisioning to provide a complete solution for the RSA problem that ensures the required QoT in MB optical networks.

Statins inhibit onco-dimerization of the 4Ig isoform of B7-H3.

B7-H3 (CD276), a member of the B7-family of immune checkpoint proteins, has been shown to have immunological and non-immunological effects promoting tumorigenesis [1, 2] and expression correlates with poor prognosis for many solid tumors, including cervical, ovarian and breast cancers [3-6]. We recently identified a tumor-cell autochthonous tumorigenic role for dimerization of the 4Ig isoform of B7-H3 (4Ig-B7-H3) [7], where 4Ig-B7-H3 dimerization activated tumor-intrinsic cellular proliferation and tumorigenesis pathways, providing a novel opportunity for therapeutic intervention. Herein, a live cell split-luciferase complementation strategy was used to visualize 4Ig-B7-H3 homodimerization in a high-throughput small molecule screen (HTS) to identify modulators of this protein-protein interaction (PPI).

The impact of the COVID-19 pandemic on access to mental health services and socioeconomic inequalities in Italy.

Objective: Comprehensive evidence on the impact of the Coronavirus Disease 2019 (COVID-19) pandemic on the use of mental health services is scarce. The aim of this study was to evaluate the impact of the COVID-19 pandemic on the access to mental health services in Italy and to assess the socioeconomic and citizenship inequalities for the same outcome.

Methods: A population-based longitudinal open cohort of residents aged ≥ 10 years was established in three large centers covering about 6 million beneficiaries (nearly 10% of the entire population) of the Italian National Health Service (NHS) from 01 January 2018 to 31 December 2021.

Gut-brain axis and neuroplasticity in health and disease: a systematic review.

The gut microbiota emerged as a potential modulator of brain connectivity in health and disease. This systematic review details current evidence on the gut-brain axis and its influence on brain connectivity. The initial set of studies included 532 papers, updated to January 2024.