Publications by authors named "A A Mughal"
The routing of blood flow throughout the brain vasculature is precisely controlled by mechanisms that serve to maintain a fine balance between local neuronal demands and vascular supply of nutrients. We recently identified two capillary endothelial cell (cEC)-based mechanisms that control cerebral blood flow in vivo: 1) electrical signaling, mediated by extracellular K-dependent activation of strong inward rectifying K (Kir2.1) channels, which are steeply activated by hyperpolarization and thus are capable of cell-to-cell propagation, and 2) calcium (Ca) signaling, which reflects release of Ca via the inositol 1,4,5-trisphosphate receptor (IPR)-a target of G-protein-coupled receptor signaling.
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- * GACI is a rare disease that results in significant arterial calcification, often leading to conditions like heart failure and pulmonary stenosis.
- * A study identified a new pathogenic variant in ENPP1 from a Pakistani family, linked to severe valvular pulmonary stenosis, confirming its role in GACI through genetic analysis and functional studies.
Article Synopsis
- A new type of brain tumor called high-grade astrocytoma with piloid features needs special DNA tests to be diagnosed.
- A 34-year-old man had headaches and dizziness, and doctors found the tumor after surgery using DNA analysis.
- The imaging tests showed specific patterns of the tumor that matched the findings in the tissue samples, helping to understand this new type of brain tumor better.
Robotic-assisted carinal reconstruction using cross-table ventilation.
Multimed Man Cardiothorac Surg
September 2024
Article Synopsis
- * Common intraoperative ventilation methods include cross-table ventilation, veno-venous extra-corporeal membrane oxygenation, and cardiopulmonary bypass; however, cardiopulmonary bypass is usually avoided due to its complications and limitations in oncological surgery.
- * The text introduces a novel technique for minimally invasive robotic carinal reconstruction that utilizes cross-table ventilation, alongside a video tutorial detailing the surgical process for a young patient with a mediastinal tumor invading the carina.
The role of 3-dimensional reconstruction imaging in bronchopulmonary sequestration.
Multimed Man Cardiothorac Surg
August 2024
Bronchopulmonary sequestration is a congenital abnormality characterized by non-functioning lung tissue, abnormal connection with the tracheobronchial tree and anomalous systemic arterial supply. Although considered a rare phenomenon presenting early in life, sequestration may also present with recurrent chest infections in late adulthood. Additionally, bronchopulmonary sequestration may rarely be incidentally encountered during thoracic surgery.
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