Publications by authors named "A A Melikyan"
During biosimilar drug development, conducting a clinical trial of biosimilar efficacy in patients may become necessary in the presence of residual uncertainty regarding the biosimilarity of the drugs. In the development of the biosimilar romiplostim GP40141, we aimed to use a model-based in silico clinical trial (ISCT) approach to optimize the planned biosimilar efficacy trial in patients with immune thrombocytopenia. The population pharmacokinetic/pharmacodynamic model for healthy volunteers was modified and validated to describe platelet dynamics in patients with immune thrombocytopenia.
View Article and Find Full Text PDFβ-Thalassemia is a disease traditionally associated with thalassemia belt countries. Nonetheless, as global migration intensifies, β-thalassemia-causing variants spread far from their origin. We investigated this process to detect some patterns underlying its course.
View Article and Find Full Text PDFThe electromagnetic field enhancement mechanisms leading to surface-enhanced Raman scattering (SERS) of R6G molecules near TiCTMXene flakes of different shapes and sizes are analyzed theoretically in this paper. In COMSOL simulations for the enhancement factor (EF) of SERS, the dye molecule is modeled as a small sphere with polarizability spectrum based on experimental data. It is demonstrated, for the first time, that in the wavelength range of500 nm-1000 nm, the enhancement of Raman signals is largely conditioned by quadrupole surface plasmon (QSP) oscillations that induce a strong polarization of the MXene substrate.
View Article and Find Full Text PDFArticle Synopsis
- Immune thrombocytopenia (ITP) leads to low platelet counts due to increased destruction and is classified based on the time post-diagnosis: newly diagnosed, persistent, and chronic.
- The TAPER trial studied eltrombopag as a treatment option for adults with ITP who didn't respond to corticosteroids, finding that about 30.5% of participants achieved a sustained response off-treatment after a year.
- Eltrombopag improved platelet counts and quality of life within a few months, with a median duration of sustained response extending to about 22 months in later follow-ups, while maintaining a safety profile consistent with prior studies.
Surgical treatment of epilepsy in children with focal cortical dysplasia in central gyri.
Zh Vopr Neirokhir Im N N Burdenko
April 2023
Unlabelled: Focal cortical dysplasias are known to be the most frequent and furtive lesions leading to intractable epilepsy in children. Epilepsy surgery in central gyri, been effective in 60-70% of cases, is still significantly challenging due to the high risk of postoperative permanent neurological impairment.
Study Aims: Assessment of the outcome after epilepsy surgery in children with FCD in central lobules.