Publications by authors named "A A McConnell"
To distinguish differences in physical and mental health between transgender and gender-diverse (TGD) veterans identified via diagnostic codes, self-identification, and their combination. We used sociodemographic characteristics and physical and mental health diagnoses for TGD veterans receiving care in Veterans Health Administration (VHA). Among the cohort of 12 745 TGD veterans, 69.
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- * Researchers identified a specific gene, ID1, that plays a critical role in the transformation process by affecting gene expression and the morphology of melanocytes, indicating its contribution to the early stages of melanoma.
- * The study's findings suggest that there are clinically undetectable precursors to melanoma that exhibit distinct traits and that targeting these precursors could lead to improved methods for early diagnosis and prevention of the disease.
The misuse of respiratory resistive loading during aerobic exercises: revisiting mechanisms of "standalone" inspiratory muscle training.
Am J Physiol Lung Cell Mol Physiol
December 2024
Article Synopsis
- Systematic reviews show that inspiratory muscle training (IMT) is beneficial for both athletes and clinical populations.
- Typically, IMT involves breathing against a resistance load twice a day for several weeks, but its use during aerobic exercise lacks solid evidence.
- The authors argue that existing advantages of IMT should not be combined with aerobic exercise, suggesting standalone IMT is more effective.
Article Synopsis
- MITF (Microphthalmia-associated transcription factor) is crucial for melanocyte function and is linked to melanoma development, helping cancer cells survive therapy by regulating antioxidant responses.
- It promotes antioxidant programs that protect melanoma cells from damage caused by reactive oxygen species (ROS), with a clear association between MITF levels and antioxidant defenses in cell lines and patient samples.
- Experimental studies, including a zebrafish melanoma model, confirm that MITF reduces ROS-related DNA damage through direct regulation of specific target genes, establishing its role in enhancing cellular antioxidant capacity.