Publications by authors named "A A Makar"
The Exposome and Cardiovascular Health: Webcast December 12 2024.
Methodist Debakey Cardiovasc J
January 2025
This 61-minute webcast features a conversation about "The Exposome and Cardiovascular Health"-the focus of Issue 20.5. Led by the issue's editors, the discussion engages the authors on emerging themes and lessons learned while researching and writing the articles.
View Article and Find Full Text PDFBackground And Objective: The 2014 Hazelwood coal mine fire exposed residents in nearby Morwell to high concentrations of particulate matter <2.5 µm (PM) for approximately 6 weeks. This analysis aimed to evaluate the long-term impact on respiratory health.
View Article and Find Full Text PDFA Review of the Links Between Work and Heart Disease in the 21st Century.
Methodist Debakey Cardiovasc J
November 2024
This review explores the multifaceted exposures in the workplace that contribute to cardiovascular diseases (CVD), including physical, ergonomics, chemical, biological, psychosocial, and emerging occupational hazards. These well-documented occupational hazards have long been linked to heart disease. Exposures arising from these hazards present significant concerns for worker health and safety.
View Article and Find Full Text PDFArticle Synopsis
- Autophagy is a vital process that helps cells break down and recycle their components, with the final step being the degradation of autophagic cargo in lysosomes.* -
- Researchers used CRISPR/Cas9 technology to identify RNAseK as a crucial transmembrane protein that regulates the degradation of autophagosomes in cells, specifically affecting cargo breakdown while leaving other lysosomal functions intact.* -
- The study found that without RNAseK, the levels of certain hydrolases decrease, and there is an accumulation of VPS4a, indicating a disruption in the delivery pathway necessary for lysosomal degradation.*
Article Synopsis
- The Hazelwood Health Study looked at how smoke from a mine fire in 2014 affected the lung health of residents over time.
- The study involved comparing people who were exposed to the smoke with those who were not and used special tests to see how well their lungs were working.
- Results showed that the more smoke people were exposed to, the more problems they had with a part of their lungs, which was similar to the effects of getting older.