Study of a genetic collection of strawberry (Fragaria L.) for resistance to powdery mildew.

Powdery mildew (Sphaerotheca macularis Mag. (syn. Podosphaera aphanis Wallr.

Polymorphism of the FaOMT and FaFAD1 genes for fruit flavor volatiles in strawberry varieties and wild species from the genetic collection of the Michurin Federal Research Center.

Fruit aroma is an important consumer attribute of strawberry varieties. The key volatile compounds of the aromatic complex of strawberry fruit are mesifurane (fruity and caramel aromas) and γ-decalactone (fruity, sweet, or peachy aroma). The mesifurane content in strawberry fruit is controlled by the FaOMT gene, which is mapped to the distal region of the long arm of chromosome VII-F.

[Exosomes secretion and autophagy in long-term protection of neurons from excitotoxic damage].

In the model of induced neuronal resistance to the toxic effect of glutamate (deprivation of trophic factors), exosome secretion is demonstrated. Exosomes are secreted at the development of resistance during deprivation and at the first 24 h after preconditioning, as was shown by dot blot of extracellular fluid using anti-CD63 antibody. The autophagy inhibitor bafilomycin (0.

[Peptide drug cortexin inhibits brain caspase-8].

Cortexin, a drug containing hydrolyzed brain peptides, has long been used in clinics, but the mechanisms of its action remain obscure. We have hypothesized that cortexin-related neuroprotection is associated with the ability of the drug to inhibit brain proteases. Cortexin effectively inhibited brain caspase-8, while its effects on caspase-1, -3, -9, cathepsin B and calpain were much less pronounced or absent.