Cell-specific delivery of GJB2 restores auditory function in mouse models of DFNB1 deafness and mediates appropriate expression in NHP cochlea.

Mutations in the gene cause the most common form of human hereditary hearing loss, known as DFNB1. is expressed in two cell groups of the cochlea-epithelial cells of the organ of Corti and fibrocytes of the inner sulcus and lateral wall-but not by sensory hair cells or neurons. Attempts to treat mouse models of DFNB1 with AAV vectors mediating nonspecific expression have not substantially restored function, perhaps because inappropriate expression in hair cells and neurons could compromise their electrical activity.

Renal Hemodynamics and Renin-Angiotensin-Aldosterone System Profiles in Patients With Heart Failure.

Objective: Understanding cardiorenal pathophysiology in heart failure (HF) is of clinical importance. We sought to characterize the renal hemodynamic function and the transrenal gradient of the renin-angiotensin-aldosterone system (RAAS) markers in patients with HF and in controls without HF.

Methods: In this post hoc analysis, the glomerular filtration rate (GFR), effective renal plasma flow (ERPF) and transrenal gradients (arterial-renal vein) of angiotensin converting enzyme (ACE), aldosterone, and plasma renin activity (PRA) were measured in 47 patients with HF and in 24 controls.

[The lymphocyte and immunoglobulin dynamics of those who participated in the cleanup of the aftereffects of the accident at the Chernobyl Atomic Electric Power Station 5 and 6 years after the irradiation].

Immunological disorders due to fall of T-lymphocytes ratio were established while IgA and IgM levels were slightly increased. B-lymphocytes ratio demonstrated tendency to normalization 6 years after irradiation.