Tourette syndrome and obsessive-compulsive disorder: A comprehensive review of structural alterations and neurological mechanisms.

Currently, it is possible to study the pathogenesis of Tourette's syndrome (TS) in more detail, due to more advanced methods of neuroimaging. However, medical and surgical treatment options are limited by a lack of understanding of the nature of the disorder and its relationship to some psychiatric disorders, the most common of which is obsessive-compulsive disorder (OCD). It is believed that the origin of chronic tic disorders is based on an imbalance of excitatory and inhibitory influences in the Cortico-Striato-Thalamo-Cortical circuits (CSTC).

Auditory Mismatch Negativity Response in Institutionalized Children.

The attunement of speech perception/discrimination to the properties of one's native language is a crucial step in speech and language development at early ages. Studying these processes in young children with a history of institutionalization is of great interest, as being raised in institutional care (IC) may lead to lags in language development. The sample consisted of 82 children, split into two age groups.

[THE IMPACT OF PERINATAL METABOLIC DISORDERS CHOICE MODE MECHANICAL VENTILATION IN NEWBORNS.].

The Aim: To study the influence of perinatal metabolic disorders, metabolism on the choice of mode of artificial lung ventilation in newborns.

Materials And Methods: The study included 73 neonates with severe respiratory failure, therefore, all children underwent ALV Depending on the mode ofventilation, patients were divided into two groups: group 1 - 33 neonates who were at the beginning of treatment on a ventilator in the SIMV mode, then led to HFO ventilation; group 2 - 40 neonates who underwent only the SIMV The study used following research methods: analysis ofpregnancy anamnestic data; clinical assessment of the newborn's condition at birth including Apgar score (AS) on the 1st minute after birth; registration of changes of mode and parameters of mechanical ventilation: a mathematical calculation of oxygenation index (0I); determination of triglycerides and cholesterol in the central venous blood of newborns in thefirst hours ofpostnatal life and on the 5th day of life Results: At birth the triglycerides level in the blood of newborns is reduced and didn't differ signicantly between the groups. Along with this,.

Paclitaxel in platinum-resistant ovarian cancer patients. Argentine Multicenter Taxol Group.

Paclitaxel (Taxol; Bristol-Myers Squibb Company; Princeton, NJ) is an antineoplastic agent that inhibits microtubular function and has shown efficacy in several solid tumors, mainly ovarian tumors, in which 20% to 40% response rates in previously treated patients were observed. We conducted a study to assess survival, response rate, and toxicity associated with paclitaxel treatment in patients with advanced ovarian cancer resistant to platinum therapy. Between September 1994 and November 1996, 38 patients were admitted for study and 37 were evaluable.