Achieving room air quality of room class Ib in the aseptic area using a mobile sterile ventilation unit in a room class II surgical unit.

Introduction: Room air class (RC) Ib may be necessary for surgical procedures in aseptic working areas. The aim of the study was to examine whether a mobile, three-stage sterile ventilation unit (MSVU) can replace a room ventilation system (RVS) with turbulent mixed flow (TMF) in the area of the operating field and on the instrument table from hygienic-microbiological point of view.

Method: During 26 surgeries (varicose vein stripping or treatment of umbilical and inguinal hernias), the microbial load was recorded at 4 measuring points (M1-M4) during regular operations by setting up sedimentation plates and measuring the particle concentration.

Online survey on barriers and drivers to flu vaccination among staff at a German university hospital during the Covid-19 pandemic 2022 (flu-vaccination motive study).

Introduction: The success of flu vaccination depends primarily on the willingness of health care workers (HCWs) to be vaccinated. To identify barriers and drivers to vaccination, an online survey among employees and students of a university hospital was performed to develop a local strategy to increase the vaccination willingness in line with the WHO recommendation.

Method: A cross-sectional, anonymous, self-administered online survey was performed among HCWs, other staff, trainees and students of the Greifswald University Hospital between 17.

Neuroimaging Augments DCD-N Score in Predicting Time from Withdrawal of Life-Sustaining Measures to Death Among Potential Organ Donors.

Background: Controlled donation after circulatory determination of death (DCD) is feasible only if circulatory arrest occurs soon after withdrawal of life-sustaining measures (WLSM). When organ recovery cannot proceed because this time interval is too long, there are potential negative implications, including perceptions of "secondary loss" for patients' families and significant resource consumption. The DCD-N score is a validated clinical tool for predicting rapid death following WLSM.

Effects of an initial anti-CD19 CAR T-cell therapy on subsequent anti-CD22 CAR T-cell manufacturing and clinical outcomes in patients with r/r LBCL.

Patients with large B-cell lymphoma (LBCL) progressing after anti-CD19 CAR T-cell (CAR19) therapy have poor outcomes. Subsequent CAR T-cell therapy shows promise, but the impact of residual CAR19 and early relapse remains unclear. We evaluated 37 CAR19-refractory LBCL patients who received anti-CD22 CAR T-cell (CAR22) in a phase 1b trial (NCT04088890).

Studies on the Virucidal Effects of UV-C of 233 nm and 275 nm Wavelengths.

Among the physical decontamination methods, treatment with ultraviolet (UV) radiation is a suitable means of preventing viral infections. Mercury vapor lamps (254 nm) used for room decontamination are potentially damaging to human skin (radiation) and harmful to the environment (mercury). Therefore, other UV-C wavelengths (100-280 nm) may be effective for virus inactivation on skin without damaging it, e.