NPTX2 transfection improves synaptic E/I balance and performance in learning impaired aged rats.

Excessive neural activity in the medial temporal lobe commonly associates with cognitive decline in elderly humans and also in rodents.An attractive model pathway to study synaptic mechanisms underlying age-dependent circuit hyperexcitability is the connection made by lateral entorhinal cortex cells onto the dentate gyrus (LEC→DG). Both structures are particularly affected by age and, importantly, in behaviorally characterized aged rats, learning impairment correlates with diminished feedforward inhibition of granule cells recruited by LEC inputs.

Risk factors for CAR T-cell manufacturing failure and patient outcomes in large B-cell lymphoma: a report from the UK National CAR T Panel.

CAR T-cell manufacturing failure (MF) is a situation where the manufacturing process fails to yield a product or results in one which is out-of-specification (OOS). We conducted a multicentre retrospective review of factors contributing to MF and patient outcomes. Of 981 large B-cell lymphoma (LBCL) patients approved for CAR T-cell therapy, 38 (3.

Erratum: Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism.

[This corrects the article DOI: 10.1016/j.isci.

Eligibility traces as a synaptic substrate for learning.

Animals can learn to associate a behavior or a stimulus with a delayed reward, this is essential for survival. A mechanism proposed for bridging this gap are synaptic eligibility traces, which are slowly decaying tags, which can lead to synaptic plasticity if followed by rewards. Recently, experiments have demonstrated the existence of synaptic eligibility traces in diverse neural systems, depending on either neuromodulators or plateau potentials.

Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism.

Alterations to the excitation/inhibition (E/I) ratio are postulated to underlie behavioral phenotypes in autism spectrum disorder (ASD) patients and mouse models. However, in wild type mice the E/I ratio is not constant, but instead oscillates across the 24-h day. Therefore, we tested whether E/I regulation, rather than the overall E/I ratio, is disrupted in two ASD-related mouse lines: KO and BTBR, models of syndromic and idiopathic ASD, respectively.