Publications by authors named "A A Khasanov"
Treatment for patients with multiple myeloma has experienced rapid development and improvement in recent years; however, patients continue to experience relapse, and multiple myeloma remains largely incurable. B-cell maturation antigen (BCMA) has been widely recognized as a promising target for treatment of multiple myeloma due to its exclusive expression in B-cell linage cells and its critical role in the growth and survival of malignant plasma cells. Here, we introduce STI-8811, a BCMA-targeting antibody-drug conjugate (ADC) linked to an auristatin-derived duostatin payload via an enzymatically cleavable peptide linker, using our proprietary C-lock technology.
View Article and Find Full Text PDFHIV-infected cells persisting in the face of suppressive antiretroviral therapy are the barrier to curing infection. Cytotoxic immunoconjugates targeted to HIV antigens on the cell surface may clear these cells. We showed efficacy in mouse and macaque models using immunotoxins, but immunogenicity blunted the effect.
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- Researchers developed a new ligand (called probe 12) based on 4-methoxyphenyl-2,2'-bipyridine that can detect zinc through fluorescence, showing a significant increase in brightness when zinc is present.
- Probe 12 has a high binding affinity for zinc, with a binding constant of approximately 2 × 10^6 M⁻¹ and a limit of detection at around 0.1 nM, outperforming a previously known probe.
- The effectiveness of probe 12 for zinc detection was confirmed through various methods, and it proved capable of identifying zinc in both live cells and fixed tissues, specifically highlighting pancreatic beta cells.
Article Synopsis
- - Solid tumors are increasingly common in various age groups and are often linked to high levels of cMET expression, complicating treatment due to the tumor's complexity and interconnected pathways.
- - The study introduces cMET-targeting Fab drug conjugates (FDCs), which combine a Fab fragment with a cytotoxic drug, investigated through both in vitro and in vivo testing.
- - FDCs show significant anti-tumor effectiveness against cMET-overexpressing cancer cells and human gastric tumors in mouse models, suggesting a promising new approach for treating solid tumors.
Polyureas (PUs) have already found wide practical applications, and various methods of their synthesis have been reported. In this manuscript, we wished to report the very first mechanochemical approach towards aromatic PUs via reactions between isomeric 2,2'-, 3,3'-, and 4,4'-diaminobiphenyls and triphosgene under solvent-free conditions following ball-milling. By using this synthetic approach, both PUs and azomethine-capped Pus were obtained.
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