Publications by authors named "A A Karelin"
Purpose: Posterior fossa tumors account for half of all childhood brain tumors, prompting the search for effective and affordable interventions to combat the neurocognitive and motor sequelae of the tumor and its treatment. The main aim of this pilot study was to evaluate the feasibility and effects of sensorimotor training incorporating cognitive tasks for a group of pediatric survivors of posterior fossa tumors.
Materials And Methods: A total of 48 participants (M= 12.
Article Synopsis
- Long non-coding RNAs (lncRNAs), specifically LINC01116 (HOXDeRNA), play a significant role in transforming human astrocytes into glioma-like cells, though their exact function is not fully understood.
- The study utilizes various advanced techniques like CRISPR and sequencing to reveal that HOXDeRNA binds to the promoters of 35 glioma-specific transcription factors (TFs), helping to activate oncogenes by releasing them from PRC2 repression.
- Findings indicate that this transformative process requires a unique RNA structure and suggests a common RNA-driven mechanism involved in gliomagenesis, shedding light on the complex development of gliomas.
The purpose of this prospective pilot study was to evaluate the feasibility and effects of cognitive-motor intervention on the cognitive and motor abilities of pediatric survivors of posterior fossa tumors. The study involved patients aged 7 to 18 years with cognitive deficits who had completed primary treatment for posterior fossa tumors. 25 participants (M=11.
View Article and Find Full Text PDFPurpose: Ataxia-telangiectasia (A-T) is an autosomal recessive disorder characterized by progressive neurological deficits, including prominent oculomotor dysfunction. We report 5 cases of eye movement assessment in children 9-15 years old with A-T.
Methods: Three different oculomotor tasks (gaze holding, visually guided saccades and visual search) were used, and video-oculography was performed.
Background: The origin and genesis of highly malignant and heterogenous glioblastoma brain tumors remain unknown. We previously identified an enhancer-associated long non-coding RNA, LINC01116 (named HOXDeRNA here), that is absent in the normal brain but is commonly expressed in malignant glioma. HOXDeRNA has a unique capacity to transform human astrocytes into glioma-like cells.
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