Selective Cytotoxicity of Medical Cannabis ( L.) Extracts Across the Whole Vegetation Cycle Under Various Hydroponic and Nutritional Treatments.

The use of L. in health care requires stringent care for the optimal production of the bioactive compounds. However, plant phenotypes and the content of secondary metabolites, such as phytocannabinoids, are strongly influenced by external factors, such as nutrient availability.

Circulating proteolytic products of carboxypeptidase N for early detection of breast cancer.

Background: Carboxypeptidase N (CPN) is important in regulating vasoactive peptide hormones, growth factors, and cytokines by specifically cleaving their C-terminal basic residues. We investigated whether circulating peptides specifically cleaved by CPN in the tumor microenvironment can be stage-specific indicators of breast cancer.

Methods: CPN activity was measured using an ex vivo peptide cleavage assay by incubating synthesized C3f peptide (His6-C3f_S1304-R1320-His6) in interstitial fluids of breast tumors and adjacent normal breast tissues in mice with orthotopic implantation of the human cell line MDA-MB-231.

[Long-term results of the surgical treatment of parasagittal meningiomas].

The article analyses the late results of surgical treatment of 123 patients with parasagittal meningiomas of various localization along the superior sagittal sinus (SSS) and falx cerebri (FC). Invalidism of patients after operations for meningiomas of the middle third of the sagittal line is still high because of stable motor defects. The results of operations for SSS resection without restoration of venous outflow of the hemisphere are poorer.

[Rehabilitative therapy after removal of parasagittal meningiomas].

A complex of restorative treatment measures applied for promoting the process of motor function restoration in patients who underwent removal of parasagittal meningiomas includes drug therapy, physiotherapy, and therapeutic exercises. The lapse of time after the operation and the specific features of the motor defect must be taken into account. The suggested complex was used in 87 patients.