Publications by authors named "A A Johar"
Coronavirus disease 2019 (COVID-19) is a highly infectious disease caused by severe acute respiratory syndrome coronavirus 2. Nasopharyngeal swabs (NP swabs) were used for patients with COVID-19 who demonstrated serious clinical symptoms and disturbances in biochemical parameters. The biochemical profiles of these patients remain ambiguous and differ from wave to wave of COVID-19 infections.
View Article and Find Full Text PDFBackground Approximately 10 million people in India suffer from bilateral blindness, with cataracts accounting for roughly 70% of these cases. However, there is a severe scarcity of ophthalmologists in India (12,000 across the country), which makes routine cataract screening very difficult, particularly in rural areas. To tackle this problem, we investigated the use of an artificial intelligence (AI)-based application for cataract screening at All India Institute of Medical Sciences (AIIMS), Bibinagar, that can be used by nursing officers and other healthcare professionals as a primary screening tool.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how cerebral amyloid angiopathy (CAA) affects recovery from ischemic stroke using a 5xFAD mouse model, hypothesizing that amyloid-beta buildup leads to worse outcomes by impairing the blood-brain barrier (BBB).
- Findings reveal that CAA worsens stroke effects, resulting in narrowed BBB microvessels, decreased cerebral blood flow, and hindered tissue recovery, alongside different gene expression patterns in endothelial cells and neural progenitor cells in the hippocampus.
- Experiments indicate that disrupting the CXCL12-PIK3C2A-CREB3L2 pathway negatively impacts neurogenesis, but activating the PI3K pathway can restore it
Introduction Hypoglycemia is a critical concern in neonatal care, particularly among preterm infants. This study aims to investigate the frequency of hypoglycemia within the first 24 hours of life in preterm neonates, considering factors such as gestational age (GA), birth weight, and gender. Materials and methods A cross-sectional study was conducted from February to August 2021.
View Article and Find Full Text PDFBackground: The presence of distinct long-term disease-specific HRQL trajectories after curative treatment for esophageal cancer and factors associated with such trajectories are unclear.
Materials And Methods: This population-based and longitudinal cohort study included 425 esophageal cancer patients who underwent curative treatment, including esophagectomy, in Sweden in 2001-2005 and were followed up until 2020, that is, 15-year follow-up. The outcomes were 10 disease-specific HRQL symptoms, measured by the well-validated EORTC QLQ-OES18 questionnaire at 6 months (n = 402 patients), and 3 (n = 178), 5 (n = 141), 10 (n = 92), and 15 years (n = 52) after treatment.