Exploring Mitochondrial Evolutionary Pathways: Insights into the Origin of the Endemic Ohrid Trout.

The Ohrid trout, , is an endemic species of Lake Ohrid, one of Europe's oldest lakes, located on the Albania-North Macedonia border. This species exhibits distinct morphotypes-, , , and -that differ in morphology and spawning behaviour. However, the extent of their genetic differentiation remains unclear.

Comprehensive analysis of prolactin receptor (PRLR) gene nonsynonymous single nucleotide polymorphisms (nsSNPs) reveals multifaceted impact on protein structure, function, and interactions.

This study delves into the functional and structural implications of non-synonymous single nucleotide polymorphisms (nsSNPs) within the Prolactin Receptor (PRLR) gene. Thirteen deleterious nsSNPs were identified through bioinformatics tools, with SIFT predicting 168 out of 395 nsSNPs as detrimental, exhibiting tolerance index (TI) scores ranging from 0 to 0.05.

Computational analysis of non-synonymous single nucleotide polymorphism in the bovine geneComputational analysis of bovine gene.

Pyruvate kinase (PKLR) is a potential candidate gene for milk production traits in cows. The main aim of this work is to investigate the potentially deleterious non-synonymous single nucleotide polymorphisms (nsSNPs) in the gene by using several computational tools. tools including SIFT, Polyphen-2, SNAP2 and Panther indicated only 18 nsSNPs out of 170 were considered deleterious.

DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer.

Ultraviolet A light is commonly emitted by UV-nail polish dryers with recent reports suggesting that long-term use may increase the risk for developing skin cancer. However, no experimental evaluation has been conducted to reveal the effect of radiation emitted by UV-nail polish dryers on mammalian cells. Here, we show that irradiation by a UV-nail polish dryer causes high levels of reactive oxygen species, consistent with 8-oxo-7,8-dihydroguanine damage and mitochondrial dysfunction.