Publications by authors named "A A Higazi"
Article Synopsis
- Inflammation is linked to dysmetabolism, and a study on transgenic mice (Def) shows that the neutrophilic peptide alpha defensin can contribute to atherosclerosis despite normal cholesterol and glucose levels.
- The study involved various assessments (metabolic, biochemical, pathological) that revealed that Def mice had lower energy expenditure and carbohydrate utilization, but higher fat oxidation, alongside abnormal levels of glucagon and other metabolites.
- The findings suggest that alpha defensin leads to hypoglucagonemia, increased fat breakdown, reduced glucose oxidation, and could serve as a model for exploring the connection between inflammation and metabolic health in atherosclerosis.
Article Synopsis
- Pulmonary fibrosis (PF) represents the final stage of interstitial lung diseases (ILDs) characterized by lung damage and scarring, with treatment focused on slowing lung function decline rather than reversing damage.
- A gene variant, rs12979860, of the Interferon lambda-3 (IFN-λ3) was linked to an increased fibrosis risk in multiple organs, but its specific role in fibrogenesis remains unclear.
- The study investigated how IFN-λ3 influences ILDs by genotyping patients and healthy controls, showing that the CC genotype associates with higher IFN-λ3 expression and increased levels of inflammatory mediators, suggesting it may drive tissue fibrosis through a feedback loop of inflammation.
: The neutrophilic peptide, alpha-defensin, is considered an evolving risk factor intimately linked with lipid mobilization. It was previously linked to augmented liver fibrosis. Here, we assess a potential association between alpha-defensin and fatty liver.
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- - Many studies link prolonged use of antiseizure medications to increased plasma homocysteine levels, which can lead to a higher risk of atherosclerosis in young individuals.
- - A study analyzed 60 epileptic children on long-term antiseizure medications and found higher levels of homocysteine, carotid thickness, and stiffness compared to healthy peers.
- - Results indicate that children on older antiseizure medications or those receiving multiple drugs face a greater risk for cardiovascular diseases, highlighting the importance of regular monitoring and potential early interventions.