Publications by authors named "A A Heirali"
Importance: Eligibility criteria for randomized clinical trials (RCTs) are designed to select clinically relevant patient populations. However, not all eligibility criteria are strongly justified, potentially excluding marginalized groups, and limiting the generalizability of trial findings.
Objective: To summarize and evaluate the justification of exclusion criteria in published RCTs in critical care medicine.
Article Synopsis
- The Canadian Critical Care Trials Group (CCCTG) aims to promote Equity, Diversity, and Inclusion (EDI) in critical care research by creating a glossary of sociodemographic determinants of health to support educational initiatives and enhance inclusive language among professionals.
- The glossary includes twelve key sociodemographic domains like age, sex, race, and income, with detailed definitions and examples related to healthcare disparities relevant to critical care.
- Developed collaboratively with various stakeholders, this resource is meant to guide critical care professionals in addressing equity issues and improving health outcomes in their practices.
Article Synopsis
- - The study focuses on understanding how sociodemographic variables, like gender identity and systemic racism, influence health outcomes for critically ill adults, highlighting the need for better data collection in critical care research.
- - Researchers will perform a scoping review to identify essential sociodemographic measures and involve various stakeholders in a modified Delphi survey to reach a consensus on core data variables (CoDaV) for health studies in critical care.
- - The study has received ethical approval from the University of Calgary's research ethics board, ensuring that the process adheres to ethical standards and findings will be disseminated effectively.
Background: Gut microbiome modulation to boost antitumor immune responses is under investigation.
Methods: ROMA-2 evaluated the microbial ecosystem therapeutic (MET)-4 oral consortia, a mixture of cultured human stool-derived immune-responsiveness associated bacteria, given with chemoradiation (CRT) in HPV-related oropharyngeal cancer patients. Co-primary endpoints were safety and changes in stool cumulative MET-4 taxa relative abundance (RA) by 16SRNA sequencing.
Background: Immune-checkpoint inhibitors (ICI) can lead to immune-related adverse events (irAEs) in a significant proportion of patients. The mechanisms underlying irAEs development are mostly unknown and might involve multiple immune effectors, such as T cells, B cells and autoantibodies (AutoAb).
Methods: We used custom autoantigen (AutoAg) microarrays to profile AutoAb related to irAEs in patients receiving ICI.