Publications by authors named "A A Hegarty"
Article Synopsis
- TAVI is a procedure designed for patients with severe aortic stenosis, particularly those who are frail, but frailty can lead to worse outcomes after the procedure.
- This systematic review analyzed studies to evaluate the effectiveness of Comprehensive Geriatric Assessment (CGA) and interventions related to it in improving outcomes for older adults undergoing TAVI.
- The review found limited evidence on the effectiveness of CGA, highlighting a need for better-designed trials to understand its impact on post-TAVI outcomes for frail older adults.
Article Synopsis
- RET is highlighted as a crucial player in breast cancer brain metastases, with overexpression linked to enhanced cancer cell adhesion and survival in the brain.
- The study utilizes various methods, including pharmacological inhibition and RNA sequencing, to explore RET's functionality and mechanisms in patient-derived tumor samples.
- Findings suggest that targeting RET could be a promising management strategy for breast cancer patients with brain metastases, particularly in those with estrogen receptor-positive tumors.
Background: There have been ongoing attempts to de-escalate surgical intervention in older breast cancer patients in recent years. However, there remains ongoing hesitancy amongst surgeons to de-implement axillary staging in this cohort. The supporting argument for performing a sentinel lymph node biopsy (SLNB) is that it may guide subsequent management.
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