Publications by authors named "A A Gordeev"
Article Synopsis
- Recent studies highlight an increasing prevalence of late-onset sepsis caused by fungal infections in immunocompromised patients, particularly concerning newborns in NICUs.
- In a study of 3,519 newborns, very low birth weight (VLBW) infants showed a significantly higher rate of invasive mycoses and funguria compared to heavier neonates.
- The research underscores the importance of monitoring fungal colonization in vulnerable infants, particularly those with low gestational age and extended NICU stays, and suggests enhancing diagnostic techniques to better identify these infections.
The global emergence of antibiotic-resistant zooanthroponotic strains, producing extended-spectrum beta-lactamases (ESBL-E) and persisting in the intestines of farm animals, has now led to the development of a pandemic of extra-intestinal infectious diseases in humans. The search for innovative probiotic microorganisms that eliminate ESBL-E from the intestines of humans and animals is relevant. Previously, we received three isolates of bifidobacteria: from milk of a calved cow (BLLT1), feces of a newborn calf (BLLT2) and feces of a three-year-old child who received fresh milk from this calved cow (BLLT3).
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- - Prolgolimab is an improved anti-PD-1 antibody that shows strong efficacy in treating metastatic melanoma and features a modified LALA mutation.
- - Comparative studies indicate that prolgolimab has higher PD-1 receptor occupancy and T-cell activation than conventional antibodies like nivolumab and pembrolizumab, while showing less activation of antibody-dependent cellular phagocytosis.
- - In mouse studies, prolgolimab inhibited tumor growth by 56%, significantly outperforming pembrolizumab's 16% inhibition, suggesting a need for clinical comparisons between IgG1 and IgG4 anti-PD-1 antibodies.
[Brain-derived neurotrophic factor in the acute and early recovery period of ischemic stroke: the role of nocturnal hypoxemia].
Zh Nevrol Psikhiatr Im S S Korsakova
June 2024
Objective: To study the relationship between brain-derived neurotrophic factor (BDNF) and the severity of nocturnal hypoxemia in patients in the acute and early recovery period of ischemic stroke (IS).
Material And Methods: We enrolled 44 patients (27 men, 17 women), aged 18-85 years, in the acute phase of IS. At 3-month follow-up, 35 people were examined (21 men and 14 women).