Nationwide survey on awareness of consanguinity and genetic diseases in Saudi Arabia: challenges and potential solutions to reduce the national healthcare burden.

Background: Consanguineous marriage is a major contributing factor for many genetic diseases and a burden to the healthcare system and national economy due to costly long-term care. Earlier studies highlighted the significantly limited awareness of the higher prevalence of genetic disease due to consanguinity even among the educated Arabs. In Saudi Arabia, more than 50% of marriages are between first cousins.

Saphenous vein versus synthetic graft in arteriovenous fistula for hemodialysis in patient with inaccessible veins.

Background: An autologous arteriovenous fistula (AVF) provides an optimal and secure way for managing the condition. An optimal blood supply to hemodialysis is linked to decreased incidence of complications and mortality, as well as reduced expenses. The objective of this research was to evaluate the outcome of people with suboptimal superficial venous system quality or who had exhausted all available arteriovenous fistula options, who received either autologous saphenous vein graft or polytetrafluoroethylene (PTFE) interposition graft as an access for effective hemodialysis.

Knowledge, attitude, and practice of asthma among the adults in Shendi locality, Sudan: A cross-sectional study.

Asthma is a chronic inflammatory condition leading to intermittent airway narrowing and obstruction. Although millions suffer from asthma globally, there is limited data from African countries, particularly Sudan. This study addresses the gap in research on asthma knowledge, attitudes, and practices among the adults in Shendi locality, Northern Sudan.

Siltuximab for Chimeric Antigen Receptor T-Cell Therapy Related CRS and ICANS - A Multicenter Retrospective Analysis.

Chimeric Antigen Receptor T-Cell therapies (CAR-T) are effective in many hematologic malignancies; however, adverse events including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) can affect a significant number of patients. Those who develop refractory CRS or ICANS have few treatment options. Siltuximab, a monoclonal antibody binding circulating IL-6, has been proposed to have clinical activity in both CRS and ICANS.