[Dose distribution in combined radiotherapy of endometrial cancer using an "Agat-B" apparatus].

The paper is devoted to a comparative analysis of dose distributions occurring during combined radiation therapy of patients with endometrial cancer. A dosimetric analysis has shown that the level of absorbed doses in a primary tumor focus is most adequately evaluated with taking due account of dose exposures in points M but not in points A. Besides it was established that the level of radiation exposure in the irradiated organ can be changed by the individual selection of schemes for the intracavitary placement of 60Co sources of higher activity.

[Prognosis in radiation injuries of the bladder and rectum in patients with cancer of the cervix uteri].

The frequency and degree of severity of radiation injuries of the urinary bladder and rectum after combined treatment of 725 patients with cancer of the uterine body are analysed. A quantitative index was worked out permitting one to give an objective evaluation of the degree of early radiation reactions of the adjacent organs. The determination of the "radiation injuries prognosis index" (RIPI) makes it possible to forecast the occurrence and degree of severity of late radiation injuries of the urinary bladder and rectum.

[Formation of dose distributions in the combined radiation treatment of patients with endometrial cancer].

The paper is concerned with some features of the dose distribution of fields of a complex shape in gamma-beam irradiation using gamma-therapeutic units and electron linear accelerators in the complex of combined radiotherapy of patients with endometrial carcinoma. The authors have performed a comparative analysis of calculated and experimental results characterizing dose fields in the utilization of individually selected forming matrices and standard splitting units. It has been shown that the utilization of the forming matrices makes it possible to optimize gamma-beam irradiation with a necessary screening of a primary tumor focus and a preset level of dose exposure in the pelvic lateral parts and zones of regional metastases.

[Tumor regression rate and the effectiveness of the radiation therapy of cervical cancer patients].

The paper deals with a correlation between the rate of tumor regression in response to radiation and the results of radiation treatment of cancer of the uterine cervix. The period of 50% decrease in tumor size in response to radiation treatment was established in 116 patients with cervical carcinoma by means of a dynamical cytological examination. Acceleration of tumor regression was followed by an increase in 5-year survival rates.

[Factors determining the probability of the development of late radiation injuries to adjacent organs in cervical cancer].

Main factors of development of late-onset lesions of the urinary bladder and rectum caused by irradiation of cervical carcinoma are discussed. The results of radiation therapy of 616 patients with cancer of uterine cervix are analysed, and the rates of incidence of late-onset radiation injuries to adjacent organs are considered in relation to dosage, methods of irradiation and early-onset radiation reactions. It was found that the frequency of late-onset radiation injuries of the urinary bladder and rectum increases in proportion to absorbed dosage of radiation and as a result of remote irradiation of the small pelvis with open fields.