Progress in quality assessment of Italian saffron.

Saffron (Crocus sativus L.) is the most expensive spice in the World, and Italy is among the major European producers. The study aims to improve value and recognition of high quality saffron by proposing a subdivision within the first quality category, according to ISO 3632 standards.

Early and Mid-Term Disposition of α-PVP and its unknown Metabolites in Urine and Oral Fluid Through a Multi-Analytical Hyphenated Approach Following a Single Non-Controlled Administration to Healthy Volunteers.

Nowadays, synthetic cathinones (SCs) is the second more representative subclass of New Psychoactive Substances, accounting for 104 analogues in the illegal market. Since its first report in 2011, α-pyrrolidinovalerophenone (α-PVP) gained popularity among drug users, provoking an increased number of intoxications. Nonetheless, pharmacokinetics data is still limited in the literature.

Minimum Overnight Interstitial Glucose Concentration in Professional Cyclists During Two Consecutive Annual Training Camps: The Limited Impact of Daily Exercise Energy Expenditure.

This observational study investigated the use of continuous glucose monitoring (CGM) in a team of professional cyclists without diabetes during two consecutive annual training camps. The goal of the study was twofold: to present the aggregated CGM metrics such as day/overnight CGM average (DAYAVG/OVNAVG) for this group of professional cyclists and to study the association between exercise energy expenditure (megajoules per day), carbohydrate intake (grams), and minimum overnight CGM values (millimoles per liter). Linear mixed models were employed in the analysis.

Evaluation of Short-Term Stability of Different Nitazenes Psychoactive Opioids in Dried Blood Spots by Liquid Chromatography-High-Resolution Mass Spectrometry.

Nitazenes represent a new synthetic opioids sub-class belonging to new psychoactive substances (NPSs). Their high pharmacological potency has led to numerous intoxications and fatalities, even at minimum doses. The aim of this study was to assess the stability of four nitazenes (etazene, flunitazene, isotonitazene and protonitazene) in dried blood spot (DBS) samples at different storage temperatures (room temperature and 4 °C) and determine the optimal storage conditions.

Driving Fatigue Onset and Visual Attention: An Electroencephalography-Driven Analysis of Ocular Behavior in a Driving Simulation Task.

Attentional deficits have tragic consequences on road safety. These deficits are not solely caused by distraction, since they can also arise from other mental impairments such as, most frequently, mental fatigue. Fatigue is among the most prevalent impairing conditions while driving, degrading drivers' cognitive and physical abilities.