Biomarkers.

Background: Harmonization of the two most commonly used Tau PET tracers, 18F-Flortaucipir and 18F-MK6240 has proven to be complex. Unlike the centiloid scale for amyloid tracers, Tau PET SUVRs of the two tracers are not linearly comparable and vary markedly in dynamic range and sensitivity.

Method: Tau PET SUVRs for Braak stage (1-6) in 18F-MK6240 and 18F-Flortaucipir were obtained from the Longitudinal multicenter head-to-head harmonization of tau-PET tracers (HEAD) project.

Biomarkers.

Background: Cellular senescence (CS) is a hallmark of aging. Senescence-associated secretory phenotype (SASP) index was recently developed based on the levels of blood SASP-related proteins. Although aging is a primary risk factor for Alzheimer's disease (AD), the role of CS in this neurodegenerative condition is not well understood.

Clinical validation of an artificial intelligence-based decision support system for diagnosis and risk stratification of heart failure (STRATIFYHF): a protocol for a prospective, multicentre longitudinal study.

Introduction: Heart failure (HF) is a complex clinical syndrome. Accurate risk stratification and early diagnosis of HF are challenging as its signs and symptoms are non-specific. We propose to address this global challenge by developing the STRATIFYHF artificial intelligence-driven decision support system (DSS), which uses novel analytical methods in determining the risk, diagnosis and prognosis of HF.

Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Mice.

5-Fluorouracil (5-FU) is an antimetabolite widely prescribed in cancer treatments, but its use in highly proliferative tissues can cause significant problems such as mucositis. is a probiotic commonly used for protection against acute diarrhea, gastrointestinal dysbiosis and inflammatory bowel diseases. We investigated the effect of on 5-FU intestinal mucositis in mice.