A Multiaxial Fatigue Damage Model Based on Constant Life Diagrams for Polymer Fiber-Reinforced Laminates.

In the last decade, fatigue damage models for fiber-reinforced polymer composites have been developed assuming the fracture energy equivalence hypothesis. These models are able to predict a fatigue life of composite laminates, but their identification requires a significant number of off-axial tests for various stress ratios. The present study proposes the stress ratio dependent model, which phenomenologically adopts a decrease in stiffness and residual strength of a unique ply according to experimental constant life diagrams.

Enhanced High-Temperature YSZ-polyester Abradable Honeycomb Seal Structures.

The abradable coatings had significantly enhanced turbomachinery performance by acting as a sacrificial seal between rotating blades and stationary casing. Further improvement in seal design to meet the higher energy demand and increase the service time has been the key challenge to solve in the gas turbine industry. Honeycomb seals have become the industry standard clearance seal technique due to their unique design and high structural strength with minimum weight.

GCH1 Deficiency Activates Brain Innate Immune Response and Impairs Tyrosine Hydroxylase Homeostasis.

The Parkinson's disease (PD) risk gene GTP cyclohydrolase 1 (GCH1) catalyzes the rate-limiting step in tetrahydrobiopterin (BH4) synthesis, an essential cofactor in the synthesis of monoaminergic neurotransmitters. To investigate the mechanisms by which GCH1 deficiency may contribute to PD, we generated a loss of function zebrafish mutant (), using CRISPR/Cas technology. zebrafish develop marked monoaminergic neurotransmitter deficiencies by 5 d postfertilization (dpf), movement deficits by 8 dpf and lethality by 12 dpf.

Private High School Reopened-COVID Mitigation and Clinical Surveillance Using an Internet Application.

Context: Recommendations for COVID-safe, in-person, high school education have included masks and distancing between students but do not describe a scalable surveillance solution to rapidly identify and mitigate disease prevalence or exposure.

Methods: Through an Internet application, all school participants reported symptoms, illness, or exposure daily. Physician-supervised follow-up interviews were reviewed and recorded in daily rounds.

[Development of an algorithm for the appointment of biofeed-back therapy and Cytoflavin for the treatment of osteochondrosis in elderly patients.].

Continuous improvement of protocols for the treatment of various ailments, in particular, osteochondrosis, is one of the important tasks of providing medical care to elderly patients. Supplementation of treatment with Cytoflavin and biofeed-back therapy seems to be a promising solution, however, it is necessary to develop an algorithm to predict it effectiveness in patients taking into account their initial clinical and psychophysiological status. As a result of the treatment, predictors of the effectiveness of the use of Cytoflavin and biofeed-back therapy have been identified and an algorithm for their administration has been developed.