Publications by authors named "A A El-Sheikh"
Nosemosis is one of the most devastating diseases of Apis mellifera (Honey bees) caused by the single-celled spore-forming fungi Nosema apis, N. ceranae and N. neumanii, causing a severe loss on the colony vitality and productivity.
View Article and Find Full Text PDFPancreatic K channel trafficking defects underlie congenital hyperinsulinism (CHI) cases unresponsive to the K channel opener diazoxide, the mainstay medical therapy for CHI. Current clinically used K channel inhibitors have been shown to act as pharmacochaperones and restore surface expression of trafficking mutants; however, their therapeutic utility for K trafficking impaired CHI is hindered by high-affinity binding, which limits functional recovery of rescued channels. Recent structural studies of K channels employing cryo-electron microscopy (cryoEM) have revealed a promiscuous pocket where several known K pharmacochaperones bind.
View Article and Find Full Text PDFChemotherapeutic drugs have demonstrated effectiveness in treating various neoplastic conditions; however, they can also have detrimental effects on male gonadal function and fertility. Consequently, interest has grown in identifying novel approaches that can mitigate chemotherapy-induced testicular damage. Thymoquinone (TQ), the chief active component of the volatile oil of (NS), has a wide range of therapeutic properties, including antioxidant, anti-inflammatory and anti-apoptotic effects.
View Article and Find Full Text PDFArticle Synopsis
- ATP-sensitive potassium (K) channels act as metabolic sensors that regulate potassium flow based on the energy status of the cell, influenced by levels of ATP and ADP.
- These channels are made up of specific subunits (Kir and SUR) that form different types with unique roles in various tissues, impacting processes like insulin release and heart function.
- The chapter outlines a protocol for using rubidium efflux assays, combined with advanced measurement techniques, to discover new compounds that could modulate the activity of K channels for potential treatments of related diseases.
Background: Biostimulation is a management practice that improves the reproductive parameters, potentiates the desire, and improves the reproductive efficiency during the short breeding season in camels.
Aim: This study aims to investigate the concurrent changes in hormonal profiles in response to management and behavioral situations on camel farms in the Eastern region of Saudi Arabia.
Methods: A total of 10 male and 50 female camels were used in this study.