Publications by authors named "A A El Kholy"
Background: Carbapenem-resistant (CRE) infections pose a significant global public health threat. We aimed to assess the risk variables, clinical characteristics, and outcomes of CRE-caused infections in criticalcare patients.
Patients And Methods: This prospective study enrolled 181 adult patients infected with in the intensive care unit (ICU).
Clinical diagnostics and biological research are advanced by magnetic theranostic, which uses macromolecule-based magnetic theranostic agents for targeted therapy and diagnostic imaging. Within this review, the interaction of magnetic nanoparticles (MNPs) with biological macromolecules will be covered. The exciting potential of macromolecule-based magnetic theranostic agents to be used as a tool in drug delivery, photothermally therapy (PTT), gene therapy, hyperthermia therapy and photodynamic therapy (PDT) will be discussed.
View Article and Find Full Text PDFTo compare the safety and efficacy of triazavirin (TZV) 250 mg capsules versus oseltamivir 75 mg capsules in the treatment of individuals diagnosed with COVID-19. A double-blind, randomized, interventional pilot study was conducted in a parallel design with a 7-day treatment period. The results showed that TZV is superior to oseltamivir regarding length of hospital stay, days until clinical symptoms improvement, and cure of chest pneumonia.
View Article and Find Full Text PDFArticle Synopsis
- The rise of carbapenem-resistant Klebsiella pneumoniae poses a significant public health risk, as carbapenems are critical for treating serious infections caused by drug-resistant bacteria.
- In a study conducted in Alexandria, Egypt, 41.5% of isolates produced strong biofilms, and 98.9% tested positive for carbapenemase production, indicating a robust virulence profile among the clinical isolates.
- Findings highlight the urgent need for effective antibiotic stewardship and infection control measures in healthcare settings to combat the spread of these dangerous pathogens.
Tuberculosis is a global public health concern. Earlier reports suggested the emergence of high rates of drug resistant tuberculosis in Egypt. This study included 102 isolates of Mycobacterium tuberculosis collected from two reference laboratories in Cairo and Alexandria.
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