[CLINICAL AND PHARMACOLOGICAL FACTORS INFLUENCING RESISTANCE TO CLOPIDOGREL IN PATIENTS WITH CARDIOVASCULAR DISEASES].

We analysed clinical and pharmacological factors influencing resistance to clopidogrel in 250 patients with cardiovascular diseases during 18 months. It was shown that the risk ofresistance depends on the form of coronary heart disease, carbohydrate metabolism, the AA genotype of CYP2C19*2 and TBS1 genes. The cardiovascular events significantly morefrequently occurred during 12 and 18 months in resistant diabetics and in the patients with an allele lacking the *2/*3 CYP2C9 gene function and AT/TT polymorphism of the thromboxane synthase gene TBS1.

[Paradoxical embolism: clinical situation and approaches to treatment].

The authors describe two clinical cases of paradoxical embolism of greater-circulation vessels in patients with thrombosis of deep veins of the lower extremities and patent foramen ovale, also discussing different variants of clinical course of paradoxical embolism, as well as approaches to treatment and prevention.

[Reproduction of trematode Leucochloridium paradoxum sporocysts (Trematoda: Leucochloridiidae)].

The histological study of the trematoda sporocysts Leucochloridium paradoxum confirmed the presence of three morphological zones in it: 1) central part (reproductive), where embryos are forming, 2) narrow tubes through which the embryos penetrate in colored broodsacs (3), where the development of metecercaria completes. It was found that germinal mass only is the reproduction organ of the sporocysts, located in reproductive zone. There are young (without embryos), mature (with embryos) and degenerated germinal masses.

[The study of hypotensive action of dinitrosyl-iron complex with glutathione containing drug oxacom in healthy volunteers].

On the basis of earlier executed studies of hypotensive effect of dinitrosyl iron complexes (DNIC) with glutathione, the drug has been created in industrial conditions named oxacom. Preliminary pharmacological studies of oxacom have not revealed negative qualities. The drug has been now tested in 14 healthy men in whom at single intravenous introduction it caused typical response - a decrease of diastolic as well as systolic arterial pressure on 24-27 mmHg through 3-4 min with subsequent very slow restoration in 8-10 hours.

[Prolongation of enoxaparin therapy to one month promotes recanalization of the occlusively thrombosed deep veins].

Aim: To compare effects of prolongation of the treatment with therapeutic doses of enoxaparin to 1 month on recanalization of occlusively thrombosed deep veins (OTDV) of the limbs with results of standard therapy with unfractionated heparin (UFH). Both treatments were followed by warfarin administration.

Material And Methods: Thirty patients were selected from 111 patients with a history of deep vein thrombosis (DVT) and/or pulmonary artery embolism according to the following criteria: the presence of occlusive thrombosis of one deep vein minimum; the absence of DVT for 12 months of follow-up.