Publications by authors named "A A Diaz-Arias"
Background & Aims: Metabolic dysfunction-associated steatohepatitis (MASH) is one of the most common liver diseases worldwide and is characterized by multi-tissue insulin resistance. The effects of a 10-month energy restriction and exercise intervention on liver histology, anthropometrics, plasma biochemistries, and insulin sensitivity were compared to standard of care (control) to understand mechanisms that support liver health improvements.
Methods: Following medical diagnosis of MASH, individuals were randomized to treatment (n = 16) or control (n = 8).
Background: Nonalcoholic fatty liver disease (NAFLD) prevalence is rapidly growing, and fatty liver has been found in a quarter of the US population. Increased liver lipids, particularly those derived from the pathway of de novo lipogenesis (DNL), have been identified as a hallmark feature in individuals with high liver fat. This has led to much activity in basic science and drug development in this area.
View Article and Find Full Text PDFmethods to estimate human liver mitochondrial activity are lacking and this project's goal was to use a non-invasive breath test to quantify complete mitochondrial fat oxidation and determine how test results changed when liver disease state was altered over time. Patients with suspected non-alcoholic fatty liver disease (NAFLD; 9 men, 16 women, 47 ± 10 years, 113 ± 23 kg) underwent a diagnostic liver biopsy and liver tissue was histologically scored by a pathologist using the NAFLD activity score (0-8). To assess liver oxidation activity, a labeled medium chain fatty acid was consumed orally (23.
View Article and Find Full Text PDFArticle Synopsis
- Patients with morbid obesity have a high risk of developing nonalcoholic fatty liver disease (NAFLD) with liver fibrosis, making effective detection methods crucial.
- A study assessed the accuracy of Fibroscan (a liver-stiffness measurement device) for diagnosing significant liver fibrosis in morbidly obese patients undergoing bariatric surgery, using liver biopsies and other evaluations for confirmation.
- Results indicated that the optimal Fibroscan cutoff for distinguishing significant fibrosis was 12.8 kPa, achieving a 71.3% accuracy with notable sensitivity and specificity, highlighting the potential of this method in clinical settings.
Background And Aims: NAFLD and its more-advanced form, steatohepatitis (NASH), is associated with obesity and is an independent risk factor for cardiovascular, liver-related, and all-cause mortality. Available human data examining hepatic mitochondrial fatty acid oxidation (FAO) and hepatic mitochondrial turnover in NAFLD and NASH are scant.
Approach And Results: To investigate this relationship, liver biopsies were obtained from patients with obesity undergoing bariatric surgery and data clustered into four groups based on hepatic histopathological classification: Control (CTRL; no disease); NAFL (steatosis only); Borderline-NASH (steatosis with lobular inflammation or hepatocellular ballooning); and Definite-NASH (D-NASH; steatosis, lobular inflammation, and hepatocellular ballooning).