Background: Asthma with neutrophilic/mixed inflammation is a difficult-to-control clinical phenotype. Currently, vascular and matrix airway remodeling in asthma with neutrophilic/mixed inflammation is not well known. We aimed to evaluate the differences in vascular/smooth muscle/matrix related asthma remodeling in eosinophilic (EOS) and mixed/neutrophilic (MIXED) bronchial phenotypes in relation to asthma severity and exacerbation frequency.
View Article and Find Full Text PDFMantle processes control plate tectonics and exert an influence on biogeochemical cycles. However, the proportion of mantle sampled in-situ is minimal, as it is buried beneath igneous crust and sediments. Here we report the lithological characteristics of two mantle sections from an embryonic ocean drilled by the International Ocean Discovery Program (IODP) in the Tyrrhenian Sea.
View Article and Find Full Text PDFOver the past 25 years, numerous biological molecules, like recombinant lysosomal enzymes, neurotrophins, receptors, and therapeutic antibodies, have been tested in clinical trials for neurological diseases. However, achieving significant success in clinical applications has remained elusive. A primary challenge has been the inability of these molecules to traverse the blood-brain barrier (BBB).
View Article and Find Full Text PDFBiology (Basel)
January 2025
End-stage liver disease (ESLD), affecting millions worldwide, represents a challenging issue for clinical research and global public health. Liver transplantation is the gold standard therapeutic approach but shows some drawbacks. Hepatocyte transplantation could be a reliable alternative for patient treatment.
View Article and Find Full Text PDFIntegr Environ Assess Manag
January 2025
Pesticides are widely used around the world and have demonstrated benefits to crop production. However, pesticides have also been associated with negative impacts to nontarget organisms, including pollinators. Here, we combined pesticide usage and toxicity data to create a toxicity index, which shows that pesticide hazard to honeybees (Apis mellifera) has changed substantially in U.
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