Publications by authors named "A A Compton"
Background: Variants in the mitochondrial genome (mtDNA) cause a diverse collection of mitochondrial diseases and have extensive phenotypic overlap with Mendelian diseases encoded on the nuclear genome. The mtDNA is often not specifically evaluated in patients with suspected Mendelian disease, resulting in overlooked diagnostic variants.
Methods: Using dedicated pipelines to address the technical challenges posed by the mtDNA - circular genome, variant heteroplasmy, and nuclear misalignment - single nucleotide variants, small indels, and large mtDNA deletions were called from exome and genome sequencing data, in addition to RNA-sequencing when available.
Species-specific interferon responses are shaped by the virus-host arms race. The human interferon-induced transmembrane protein (IFITM) family consists of three antiviral IFITM genes that arose by gene duplication. These genes restrict virus entry and are key players in antiviral interferon responses.
View Article and Find Full Text PDFHaynes, H, Tinsley, GM, Swafford, SH, Compton, AT, Moore, J, Donahue, PT, and Graybeal, AJ. Mobile anthropometry in Division I baseball athletes: evaluation of an existing application and the development of new equations. J Strength Cond Res XX(X): 000-000, 2024-The purpose of this study was to evaluate the agreement between mobile application and dual-energy x-ray absorptiometry (DXA)-derived body composition parameters in a group of Division I (DI) collegiate baseball athletes and to develop new equations for this population using this mobile technique.
View Article and Find Full Text PDFArticle Synopsis
- * Research reveals that the CD225 domain harbors a SNARE-like motif, enabling interactions with SNARE proteins, which are essential for membrane fusion; this is particularly important in diseases linked to mutations in these regions, such as neurological disorders.
- * One member, IFITM3, is shown to interact with SNARE proteins to protect against influenza A virus by disrupting SNARE complex assembly and enhancing endosomal cargo movement to lysosomes, suggesting a key role for SNARE modulation in the diverse functions of CD225
Article Synopsis
- Near-infrared reactance spectroscopy (NIRS) is gaining popularity for body composition assessments, but it's unclear how well it matches with established methods like DXA.
- The study involved 97 participants using both NIRS and DXA for body composition analysis, with a subset performing muscle quality tests.
- Results showed that NIRS measurements for fat mass and fat-free mass were similar to DXA, highlighting potential for NIRS as an alternative method, although some differences in muscle quality indices were noted.