Publications by authors named "A A Chukhlovin"
Carbapenem-resistant (CRE) are a global health threat due to their high morbidity and mortality rates and limited treatment options. This study examines the plasmid-mediated transmission of virulence and antibiotic resistance determinants in carbapenem-resistant () and () isolated from Russian hospitals. : We performed short- and long-read whole-genome sequencing of 53 clinical isolates (48 and 5 ) attributed to 15 genetic lineages and collected from 21 hospitals across nine Russian cities between 2016 and 2022.
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- Dose-intensive therapies during allogeneic hematopoietic stem cell transplantation (allo-HSCT) significantly disrupt gut microbiota and promote antibiotic resistance, with recovery patterns poorly understood.
- In a study of 12 adult patients, stool samples revealed a marked decline in microbial diversity starting from day 0, persisting for up to a year, with specific bacterial genera showing slower recovery.
- A rise in antibiotic-resistant bacteria was observed around day 30 post-transplant, with resistance to major antibiotic classes, but a gradual decrease in resistance levels was noted over the following year.
Article Synopsis
- A pilot clinical study showed that oral microbiota transplantation from a healthy mother to her 6-month-old child with neuroblastoma can safely prevent chemotherapy-induced oral mucositis.
- The patient received oral donor saliva during chemotherapy cycles, which led to a significant reduction in the severity of oral mucositis, only experiencing mild symptoms after hematopoietic cell transplantation.
- The study also revealed changes in the patient's oral bacteria, with an increase in beneficial bacteria and a decrease in harmful strains, and no adverse effects from the transplantation were reported.
Inflammatory bowel diseases (IBD) and acute graft-versus-host disease (GVHD) are associated with persistent intestinal dysfunction preceded by gut bacterial dysbiosis. There are limited data on intestinal bacteriophages in these conditions. The aim of the present work was to detect associations between dominant intestinal bacteria by means of 16S rRNA gene sequencing, and some clinically significant viruses detected with a customized primer panel for NGS-based study.
View Article and Find Full Text PDFPost-transplant сyclophosphamide after matched donor hematopoietic stem cell transplantation in children with acute leukemia.
Clin Transplant
January 2024
Article Synopsis
- - The study investigates the effectiveness of post-transplant cyclophosphamide (PTCy) in preventing graft-versus-host disease (GVHD) in pediatric acute leukemia patients who underwent matched allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- - A retrospective analysis of 190 children shows that PTCy-based GVHD prophylaxis led to significantly lower rates of acute and chronic GVHD after transplants from matched unrelated donors (MUD) compared to standard treatments.
- - The findings suggest PTCy is a promising and effective option for GVHD prevention in pediatric patients, particularly in MUD settings, while showing similar efficacy to traditional methods in matched sibling donor (MSD) transplants. *