Left atrial appendage occlusion in patients with atrial fibrillation and intracerebral haemorrhage associated with cerebral amyloid angiopathy: a multicentre observational study and pooled analysis of published studies.

Background: Cerebral amyloid angiopathy (CAA) is a common cause of intracerebral haemorrhage (ICH) with a high recurrence risk. Left atrial appendage occlusion (LAAO) is a method for ischaemic stroke prevention in patients with atrial fibrillation (AF), potentially reducing the risk of intracranial bleeding in CAA-associated ICH. We aimed to determine the outcomes of patients with AF with CAA-associated ICH undergoing LAAO.

Acute hepatitis of unknown aetiology in children: evidence for and against causal relationships with SARS-CoV-2, HAdv and AAV2.

Background: The cause of acute paediatric hepatitis of unknown aetiology (2022) has not been established despite extensive investigation.

Objective: To summarise the evidence for and against a causal role for human adenovirus (HAdv), adeno-associated virus 2 (AAV-2) and SARS-CoV-2 in outbreaks of paediatric hepatitis in 2022.

Methods: We appraised and summarised relevant evidence for each of the Bradford Hill criteria for causality using quantitative (statistical modelling) and qualitative (narrative coherence) approaches.

CK5/6 Expression in Molecular Subtypes of Invasive Ductal Carcinoma.

Background Breast cancer (BC) is the leading cause of cancer-related deaths in women worldwide. There has been a significant increase in the incidence of BC in Pakistan. Family history, older age, obesity, tobacco use, oral contraceptive use, early menarche, and hormonal replacement therapy are among the major risk factors.

CORRELATION BETWEEN FACIOLINGUAL INCLINATION OF MAXILLARY CENTRAL INCISORS AND MOLARS WITH MAXILLARY AND MANDIBULAR MORPHOLOGY.

Background: The torque of maxillary incisors and molars forms an important component of smile esthetics. The inclination of these teeth may be affected by maxillary and mandibular dimensions. The study aimed to evaluate the correlation between the faciolingual inclinations of maxillary incisors and first molars with palatal width (PW), palatal depth (PD), maxillomandibular angle (MMA) and mandibular width (MW) using cone beam computed tomography scans.

Expression of β-Catenin in Salivary Gland Tumors.

Introduction: Salivary gland tumors are an important group of neoplasms in the head and neck region. This study aims to assess the significance of β-catenin expression in both benign and malignant salivary gland tumors.

Materials And Methods: We included 80 reported cases of benign and malignant salivary gland tumors and employed β-catenin stain on tumor blocks.