[Changes in activity of transcription factors in the cells of vascular endothelium as a pathological mechanism of its dysfunction in essential hypertension].

Aim: To study activity of transcription factor (TF)--the nuclear factor kappa B (NF-kB)--and its role in formation of endothelial dysfunction (ED) in patients with essential hypertension (EH).

Material And Methods: The examination covered 74 patients with EH stage I-II with the first-third degree of arterial hypertension (AH) by WHO/IHS classification (48 males, 36 females, mean age 46.39 +/- 3.

[Remodeling of elastic arteries in patients with hypertensive disease: diagnostic value of pulse pressure].

The study was undertaken to examine a role of pulse blood pressure (PBP) as a diagnostic marker of remodeling of large elastic arteries in patients with hypertensive disease (HD). A hundred and sixty-eight patients with HD and 38 apparently healthy individuals (a control group) were examined. In all the examinees, PBP was measured and central PBP (PBPc) was calculated.

[Structural and functional reconfiguration of large arteries in hypertensive disease: a role of connective tissue metabolic disturbances].

The study was undertaken to define a role of connective tissue metabolism (CTM) in the structural and functional changes of arterial vessels in patients with hypertensive disease (HD). Eighty-nine patients with HD and 33 apparently healthy individuals were examined. The morphometrical parameters of the aorta were studied by magnetic resonance imaging (MRI), external and internal diameters (ED and ID, respectively) and the thickness of the wall (Hao) at the level of the ascending aorta and its mass (Mao) were determined.

[Effects of nebivolol, metoprolol and enalapril maleate on the state of endothelium-dependent arteriolar vasodilation in patients with essential hypertension].

Effects were studied of nebivolol, metoprolol and enalapril maleat on the state of endothelium-dependent vasodilatation of arterioles in patients with essential arterial hypertension. Nebivolol has been shown to effectively decrease blood pressure and restore endothelium-dependent vasodilatation to a grater degree, than enalapril or metoprolol.

[Clinical significance of urinary albumin excretion in patients with essential hypertension].

In the studies made, the role of microalbuminuria as a diagnostic marker of greater load of essential hypertension in the examined patients has been ascertained.