De novo protein design by citizen scientists.

Online citizen science projects such as GalaxyZoo, Eyewire and Phylo have proven very successful for data collection, annotation and processing, but for the most part have harnessed human pattern-recognition skills rather than human creativity. An exception is the game EteRNA, in which game players learn to build new RNA structures by exploring the discrete two-dimensional space of Watson-Crick base pairing possibilities. Building new proteins, however, is a more challenging task to present in a game, as both the representation and evaluation of a protein structure are intrinsically three-dimensional.

[Hybrid procedures for aortic arch disease].

Different surgical approaches for aortic arch disease were reviewed in the article. We have also compared various vascular prostheses for aortic replacement.

Three-months optical coherence tomography analysis of a biodegradable polymer, sirolimus-eluting stent.

Objective: We aimed to assess early neointimal healing by optical coherence tomography (OCT) 3 months after implantation of the ultrathin Orsiro® sirolimus-eluting stent with biodegradable polymer.

Background: New generations of drug-eluting stents with biodegradable polymer have been developed to avoid the continued vascular irritation of durable polymers.

Methods: In this prospective, open-label study, 34 patients received an Orsiro® sirolimus-eluting stent with biodegradable polymer.

[The ultrastructure of components of the tracheobronchial tree epithelium].

The paper reviews the data available in the literature on the ultrastructure of the epithelium of the tracheobronchial tree and deals with morphological and functional characteristics of 12 cell types making up the epithelium.