Publications by authors named "A A Belousova"
Under the influence of inflammation, pancreatic β cells can transdifferentiate into cells with a different phenotype. When inflammation decreases, the opposite process is possible. We studied the effect of intramuscular injection of 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt (APH) on the structural and functional characteristics of the pancreatic islets in rats with experimental type 2 diabetes mellitus.
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- Researchers developed a new ligand (called probe 12) based on 4-methoxyphenyl-2,2'-bipyridine that can detect zinc through fluorescence, showing a significant increase in brightness when zinc is present.
- Probe 12 has a high binding affinity for zinc, with a binding constant of approximately 2 × 10^6 M⁻¹ and a limit of detection at around 0.1 nM, outperforming a previously known probe.
- The effectiveness of probe 12 for zinc detection was confirmed through various methods, and it proved capable of identifying zinc in both live cells and fixed tissues, specifically highlighting pancreatic beta cells.
Structures and stability of mixed group 13-14-15 element hydrides PBEH (E = C, Si, Ge), their oligomers, and complexes with Lewis acids and Lewis base are computationally studied at the B3LYP-D3/def2-TZVP level of theory. Unsubstituted chain hydrides are unstable and are expected to form cyclic oligomers. Cyclization can be prevented by the donor-acceptor complex formation.
View Article and Find Full Text PDFUrbanization processes in Asia are still ongoing; thus, aggregate demand is expected to increase in following years. Even though construction and demolition waste is a source for secondary building materials in industrialized countries, it is not yet an alternative construction material source in Vietnam as the urbanization process is still ongoing. Thus, there is a need for river sand and aggregates alternatives in concrete, namely manufactured sand (m-sand) from primary solid rock materials and secondary waste materials.
View Article and Find Full Text PDF4-Arylhydrazinylidene-5-(polyfluoroalkyl)pyrazol-3-ones (4-AHPs) were found to be obtained by the regiospecific cyclization of 2-arylhydrazinylidene-3-(polyfluoroalkyl)-3-oxoesters with hydrazines, by the azo coupling of 4-nonsubstituted pyrazol-5-oles with aryldiazonium chlorides or by the firstly discovered acid-promoted self-condensation of 2-arylhydrazinylidene-3-oxoesters. All the 4-AHPs had an acceptable ADME profile. Varying the substituents in 4-AHPs promoted the switching or combining of their biological activity.
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