EVALUATION OF THE EFFECT OF REBAMIPIDE ON THE PROGRESSION OF ULCERATIVE COLITIS IN RATS IN THE EXPERIMENT.

Rebamipide contributes to the improvement of blood supply of the GI mucosa, activates its barrier function, activates alkaline secretion of the stomach, increases proliferation and metabolism of epithelial cells of the GI tract, cleanses the mucosa from hydroxyl radicals and suppresses superoxides, produced by polymorphonuclear leukocytes and neutrophils in the presence of Helicobacter pylori, protects the GI mucosa from bacterial invasion and the damaging effects of non-steroidal anti-inflammatory drugs (NSAIDs) on the mucosa. Rebamipide, originally developed as a treatment for gastric ulcers, has attracted the attention of researchers as a potential drug for the treatment of UC due to its ability to stimulate mucus production, reduce oxidative stress, and decrease inflammation. Due to the presence of these properties, it is hypothesized that rebamipide may have a protective effect on the intestinal mucosa during prolonged inflammation, making it a promising candidate for inclusion in therapeutic strategies for ulcerative colitis.

[Fauna and distribution of nematodes from the suborders spirurata and filariata parasitizing cattle in Dagestan, from the perspective of vertical zoning].

Cattle of Dagestan are infested with several nematode species from the suborders Spirurata and Filariata, and extensiveness of the invasion depends greatly on the altitude above sea level. Level of infestation with Thelazia rhodesi, Th. gulosa, and Th.

[Primary renal osteosarcoma].

A rare case of a primary kidney osteosarcoma with fusiform and bone component is described in a 38-year-old male.

[Prognostic factors in bladder cancer].

DNA distribution was studied in tumor cells of 54 patients with bladder cancer. Diploid and aneuploid distributions were recorded in 34 and 20 cases, respectively. Aneuploid DNA proved to be a negative prognostic factor as 5-year survival of such patients made up 48.